@JABLab3

Jen A-Brett MD PhD ATSF | 🫁 transplant & critical care | mechanisms of #chronic airway disease | cytokines and extracellular vesicles | @CSCTR_org President

 St Louis, MO
sites.wustl.edu/jablab
Joined August 2018
  • Tweets1.1K
  • Following786
  • Followers532
AP-1 TFs control everything, example #312: nature.com/articles/d41586-0… nature.com/articles/s41586-0…

Remembrance of inflammations past

Nature - Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation.

nature.com
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EXOKĒRYX@exokeryx
Mar 19
With just a few minutes of hands-on set-up, #DemeterEVPrep's hands-off, automated workflow isolates #EVs from up to 8 samples simultaneously. Visit us at @SelectBio's Next-Gen Instruments & Tools Driving EV Research 2026 to learn how Demeter EVPrep can speed your discovery. 🔗👇
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Science News@SciencNews
Jan 5
How to write an excellent Review article #PhD #phdlife #postdoc #Science #academia
Science News@SciencNews
Jan 4
How to Write Your First Research Paper. #phdlife #PhD #academic #academictwitter #Science #research
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Science News@SciencNews
Jan 6
How to Be a Graduate Advisee
Science News@SciencNews
Jan 4
How to Pick a Graduate Advisor #PhD #Science #academia #phdlife
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A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies. Learn more in a new #SciencePerspective: scim.ag/4j8UAA6
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Spermidine deficiency induces BNIP3/LC3B-mediated mitophagy in the salivary glands of accelerated aging mice sciencedirect.com/science/ar…
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Dr. Dominic Ng
@DrDominicNg
Jan 2
New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep). Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep. They found what actually matters - and why some sleeping pills might undermine it 🧵
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Organ-specific proteomic aging clocks predict disease and longevity across diverse populations nature.com/articles/s43587-0…
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Is fibroblast proliferation important in pulmonary fibrosis? Finally an answer - great paper by the super team of Christopher Molina,Tatsuya Tsukui, and Dean Sheppard #זScienceMatters #CureIPF jci.org/articles/view/191826
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Lior Pachter@lpachter
22 Nov 2025
Academic flexes that I dislike: 1/🧵
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🌎 Today is #WorldAlzheimersDay! Make a gift in honor of the 55 million people worldwide living with Alzheimer’s or another dementia and have DOUBLE the impact on accelerating research and helping provide vital care and support: bit.ly/4pDc2iY. #ENDALZ
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I recently learned that the novelist, Cormac McCarthy, spent several years at the Santa Fe Institute helping scientists write papers. His advice was condensed into a brief Nature column. The first three points, and some of the final points, are really good. (h/t @eryney_ok)
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The management of ascites in patients with cirrhosis can get tricky. When they're hospitalized, whether in the wards or the ICU, striking a balance is a delicate one. This article details an algorithm for this. 🎩 tip to the authors. eddyjoemd.com/foamed
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Why do only certain molecules drive allergies? A feature now identified among some allergy-causing proteins is their ability to form pores in cells. @NatureNV @bart_lambrecht nature.com/articles/d41586-0… @Nature nature.com/articles/s41586-0…
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How does IL-33 turn up the heat in airway disease? @jablab3 @omar_ohhh @washumedicine analyzed lung specimens from patients with chronic obstructive pulmonary disease and asthma, revealing heat shock protein 70 as a chaperone for IL-33 activity in chronic airway disease: insight.jci.org/articles/vie…
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"For half an hour, I vented everything I had been holding in for months … my supervisor listened patiently, then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." #ScienceWorkingLife scim.ag/47vf7L6
An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

ALT An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

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Eric Topol
@EricTopol
14 Aug 2025
Platelets sequester and harbor cell-free tumor DNA, which could enhance our ability to make early, microscopic diagnosis of cancer @ScienceMagazine science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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ATS AII@ATS_AII
14 Aug 2025
🚨🚨🚨Breaking News🚨🚨🚨 Brensocatib has become FDA-approved for the treatment of bronchiectasis!
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Joao Pereira
@jdpereira
11 Aug 2025
So, on the left we have spinning cortical organoids (control) which we tried to… stress out. On the right, the same approach to stress out organoids carrying a mutation in the protein TDP-43, associated with ALS and FTD. Notice anything? Wonderful work by Russell D’Souza!
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An antigen-presenting cell subtype tames the immune response to food antigens in early life. Learn more in a new #SciencePerspective: scim.ag/3IyZY0Y
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