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KlenermanLab

@KlenermanLab

Our research group develops single-molecule methods to address important biological issues, from neurodegenerative disease to how immune responses are triggered

 University of Cambridge, UK
klenermangroup.co.uk
Joined January 2019
  • Tweets185
  • Following85
  • Followers1.1K
🚨 NEW PAPER ALERT 'Detecting alpha-synuclein aggregates with small molecules on single-molecule array': doi.org/10.1039/D4SC07649D Excited to share this @KlenermanLab & Hunter Lab @ChemCambridge collaboration. 1/🧵
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➡️ Read our new paper here: pmc.ncbi.nlm.nih.gov/article…
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease

The monoclonal antibodies Aducanumab, Lecanemab, Gantenerumab, and Donanemab were developed for the treatment of Alzheimer's disease (AD). We used single‐molecule detection and super‐resolution...

pmc.ncbi.nlm.nih.gov
UK Dementia Research Institute (@UKDRI) profile pictureUK Dementia Research Institute
@UKDRI16 Apr 2025
🧠 Lecanemab prefers to bind to a certain size of toxic protein found in people with early-stage Alzheimer’s, new research by @KlenermanLab & Prof Bart De Strooper reveals. The study provides vital new insight into how different anti-amyloid drugs work👉buff.ly/E9OrL2G
Image from UK Dementia Research Institute (@UKDRI)
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Wow! First session at #ADPD2025 & Florence Layburn @FlorenceLayburn from the @KlenermanLab is sharing new data using their new SIMPull method to look at the detection of soluble Tau aggregates in #Parkinsons. Very impressive presentation from this young PhD student!
Image from The Science of Parkinson's (@ScienceofPD)
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Witnessing an unforgettable moment when Prof Sir David Klenerman @KlenermanLab and Prof Sir Shankar Balasubhramaniam took us all through a journey of a few decades. The ups and downs, the importance of socialization, and most importantly the power of simple ideas -(1/2)
Image from Arpan Dey, PhD (@via_ADs_lens)
Image from Arpan Dey, PhD (@via_ADs_lens)
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What a wonderful talk!! Dorothea Boeken (@KlenermanLab) @Cambridge_Uni, advanced single molecule-super resolution Tau image assay. UNVEILING THE MOLECULAR LANDSCAPE OF TAU AGGREGATES IN ALZHEIMER’S DISEASE AND OTHER TAUOPATHIES. @UKDRI #ADPD2025 @adpdnet 🎉
Image from Kei Cho Lab (@ChoLab_Synapse)
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Replying to @KlenermanLab
@KlenermanLab out in force @adpdnet #ADPD2025 🇦🇹 Look out for talks from Beatrix & Dorothea tomorrow 👀
Group of 11 researchers from the Klenerman Lab, Cambridge, in the foyer of the ADPD 2025 conference

ALT Group of 11 researchers from the Klenerman Lab, Cambridge, in the foyer of the ADPD 2025 conference

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🇦🇹 At #ADPD2025? Talks and posters on single-molecule aggregation to look out for from @KlenermanLab (@UKDRI @ChemCambridge)🧵⬇️
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🗣️ Dorothea Boeken (@DorotheaBoeken), PhD student, on tau in Alzheimer’s disease and other tauopathies 🗓️ Fri 4 🕗 2:40 pm 🧫 Session: Tau aggregation 📍 Hall F1
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🗣️ Beatrix Huissoon, PhD student, on TNFa effects on aggregation in cerebral organoids 🗓️ Fri 4 🕗 5:20 pm 🧫 Session: Disease mechanisms 📍 Hall C
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SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al at @Cambridge_Uni @ucl @univofstandrews dlvr.it/THYqLv

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using...

Connections between nerve cells are highly damaged in Alzheimer’s and Parkinson’s disease. This is believed to be linked to the formation of small-soluble aggregates of disease-related proteins....

cell.com
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Scientists led by @KlenermanLab have developed a new biomarker to measure brain inflammation in Alzheimer's & Parkinson's 🧠 👏 It could improve diagnostics and help test new therapies in clinical trials: 👉 buff.ly/4i8aycL
Image from UK Dementia Research Institute (@UKDRI)
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Interesting: @KlenermanLab et al establish an ultra-sensitive single-molecule pull-down immunoassay combined with dSTORM microscopy assayed human post-mortem brain, serum & CSF of #Parkinsons, #Alzheimers & elderly individuals for inflammasome ASC specks nature.com/articles/s41467-0…
Image from The Science of Parkinson's (@ScienceofPD)
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A new pilot study from @KlenermanLab et al tested an antibody-based single-molecule pulldown assay to quantify salivary α-synuclein & amyloid-β peptide aggregate numbers (#Parkinsons & #Alzhiemers); Saliva aggregates retain relevant structural information academic.oup.com/braincomms/…
Image from The Science of Parkinson's (@ScienceofPD)
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Different Viewpoints: The David Klenerman and Shankar Balasubramanian Story 🧬 youtu.be/FgGO2QtudAM?feature… via @InventorsHOF
Different Viewpoints: The David Klenerman and Shankar Balasubramanian...

Different Viewpoints: The David Klenerman and Shankar Balasubramanian...

David Klenerman and Shankar Balasubramanian co-invented Sequencing-...

youtube.com
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Just a few weeks until the National Inventors Hall of Fame® Induction Ceremony! Take another look at this year’s class of Inductees before the big event on May 9. bit.ly/2H9x0Si #NIHF2024
Image from Inventors HOF (@InventorsHOF)
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In just 10 years, 2024 Inductee David Klenerman & co-inventor Shankar Balasubramanian transformed a concept on paper into pioneering the Sequencing-by-Synthesis method for #DNA sequencing. Explore the remarkable journey of this newest Inductee! #NIHF2024 bit.ly/4aNmDA6
Image from Inventors HOF (@InventorsHOF)
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Having a lifelong affinity for science, #NIHF2024 Inductee David Klenerman pursued chemistry @Cambridge_Uni, graduating with a bachelor’s degree in 1982. Returning in 1994, he currently serves as a professor of biophysical chemistry & is a group leader at the @UKDRI.
Image from Inventors HOF (@InventorsHOF)
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