@Kyrillus2
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Clinical Lecturer in Cancer Sciences @UoGlasgow, Honorary Medical Oncologist @NHSGGC, ex-Fellow @TheChristieNHS, @ASCO-LIFe Fellow @WeillCornell.
Glasgow
Joined July 2017
- Tweets445
- Following1.6K
- Followers567
- Likes744
Kyrillus Shohdy, MD retweeted
Clinician scientist training is under threat: this analysis reviews the outcomes of a 25 yearcohort of the UCL MB-PhD program from 1995 : a long-term investment in the clinician-scientist workforce medRxiv medrxiv.org/content/10.64898…
Kyrillus Shohdy, MD retweeted
Thrilled to share our latest work is out today in @Nature
ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer.
nature.com/articles/s41586-0…
Kyrillus Shohdy, MD retweeted
An RNA-editing enzyme restrains the excessive proliferation of intestinal stem cells—a major hallmark of #aging in humans and other organisms—according to new work involving fruit flies and data from mice and human samples. @IHuaXi scim.ag/4x2MTkw
Kyrillus Shohdy, MD retweeted
A previously unrecognized estrogen-dependent signaling pathway in the gut regulates visceral pain sensitivity in mice, according to a new Science study. The findings provide a pathway toward targeted therapeutic strategies.
📄: scim.ag/4rTYSz4
#SciencePerspective: scim.ag/4j8UAA6
Kyrillus Shohdy, MD retweeted
Cancer cell plasticity and resistance to KRAS inhibition
Two recent preclinical examples in #ColorectalCancer
@CD_AACR
aacrjournals.org/cancerdisco…
@Cancer_Cell
cell.com/cancer-cell/fulltex…
Kyrillus Shohdy, MD retweeted
🔥off the press🔥
Cholangiocarcinoma 2026: status quo, unmet needs and priorities
@NatRevGastroHep
doi.org/10.1038/s41575-025-0…
👉get the lastest, most comprehensive summary on cholangiocarcinoma
👏fantastic team effort!
@myESMO @EASLedu @ILCAnews
Kyrillus Shohdy, MD retweeted
How can a gene mutation be present throughout the body yet cause cancer only in certain tissues? This is exactly the challenge our SPECIFICANCER team took on 7 years ago.
Read the newly published impact report from the team that reshaped our understanding of tissue specificity to pioneer potential new cancer treatments.
Thank you to everyone involved for driving this ambitious science forward. Thanks also to our co-funders, @TheMarkFdn, for supporting the #CancerGrandChallenges SPECIFICANCER team and global science.
Read the report: lnkd.in/eDrQ9guu
Kyrillus Shohdy, MD retweeted
Systemic review on neurocognitive outcomes in patients with🧠 metastases in @TheLancetOncol
Urgent need for research assessing modality-specific neurocognitive tox and optimal sequencing of therapies!
@OncoAlert
#brainmets
thelancet.com/journals/lanon…
Kyrillus Shohdy, MD retweeted
What’s true in #PancreaticCancer precursor lesions is also true in #ColorectalCancer precursor lesions. @cncurtis @SnyderShot @StanfordMed demonstrate polyclonal origin of adenomas in patients with FAP.
Cancer as a manifestation of convergent evolution!
nature.com/articles/s41586-0…
Groundbreaking work just came today from @owen_sansom Lab, spearheaded by Mark White and exceptionally talented team @CRUKScotland & @UoFGlasgow
The work unmasked MAPK-driven Colorectal Cancer's clever escape from therapy. Yes Always search for the WNT.
nature.com/articles/s41586-0…
Kyrillus Shohdy, MD retweeted
Very proud of all our hardwork! Exciting new paper exploring the origin of liver cancer nature.com/articles/s41586-0…
@owen_sansom
Kyrillus Shohdy, MD retweeted
Paneth-like transition drives resistance to dual targeting of KRAS & EGFR in CRC
✅CRC cells surviving combined KRAS & EGFR inhibition acquire Paneth-like state
✅SMAD1-FGFR3 axis triggers Paneth-like plasticity
✅FGFR3 blockade could overcome plasticity-driven drug tolerance
@OncoAlert @Cancer_Cell
cell.com/cancer-cell/fulltex…
Kyrillus Shohdy, MD retweeted
Provocative new data in @NatureMedicine from @JenWargoMD @nadim_ajami & colleagues @MDAndersonNews
Microbial signals in primary and metastatic brain tumors
nature.com/articles/s41591-0…
Orthogonal validation using multiple platforms provides support for this observation
Kyrillus Shohdy, MD retweeted
📌Inaccurate lymph node clinical staging in early and intermediate-risk rectal cancer
@EORTC
🚨19.5% understaged and 62.4% overstaged
✅Seems no survival effect
➡️At least a destressing data when MRI shows 1-3 small lymph nodes that we can not decide whether pathologic or not
👉ejcancer.com/article/S0959-8…
#cancer #oncology #MedX #rectal @OncoAlert @realbowtiedoc @GIMedOnc
Kyrillus Shohdy, MD retweeted
ANOVA in R! 💪 in ONE LINE OF CODE!
ggstatsplot::ggbetweenstats(ISLR::Wage, race, wage)
Watch the video for more details: youtu.be/JDGtLG0Tceo
#rstats #statistics #dataanalysis #stats #datascience #r4ds
Kyrillus Shohdy, MD retweeted
🍽️ Turning “no appetite” into “pass the plate” with olanzapine
📝 JNCCN 2025 | OlAnCa trial | DB RCT | n=164 | Cairo Univ
🔑 Trial essentials
• 🌐 Incurable solid tumors + cachexia
• 🎲 Randomized: Olanzapine 5 mg QHS vs placebo
• 🎯 Primary: Appetite (ESAS-Anorexia) @ 1 wk
📊 Results
🍴 Appetite ↑ more with olanzapine (–2 vs –1; p=0.003)
⚖️ ≥5% weight gain: 14% vs 0% (p=0.008)
😀 QoL (FAACT-ACS) improved
💪 BUT ↓ handgrip strength (–2.8 kg) & ↑ grade ≥3 anemia/leukopenia
💡 Takeaway
Olanzapine 5 mg = rapid appetite & weight gains in cachexia — but ⚠️ safety & durability remain open questions.
📓Othman NO, et al. JNCCN. 2025;23(9):385–392.
🔗DOI: jnccn.org/abstract/journals/…
#OncoTwitter #MedTwitter #PalliativeCare #Cachexia
@OncoAlert @myesmo @asco @JNCCN
Kyrillus Shohdy, MD retweeted
#USCAP2025 w/ Dr Voltaggio
Esophageal ⬆️ grade dysplasia/intramucosal adeno → treated with EMR. Presence of muscularis mucosa = lateral margin; large vessels + loose CT = deep margin. Recommendation to pin specimen before fixing for easier margin assessment.
#PathWebinarPearls
Kyrillus Shohdy, MD retweeted
New review: Mellor, Larson, and @DrMengWang discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. hubs.la/Q03D97r20
#CellMetabolism
Kyrillus Shohdy, MD retweeted
New Paper Alert: BRCA1/2 Mutations and RB1 Alterations Predict Poorer Outcomes With Endocrine Therapy ± CDK4/6 Inhibitors in HR+/HER2– Breast Cancer
Authors: Hamdy A. Azim, Hagar Elghazawy (@HagarElghazawy1), Kyrillus S. Shohdy (@Kyrillus2 ) Shaimaa Lasheen, Mahmoud Elghazawy, Ramy Ghazy, Dalia Abdelnasser, Loay Kassem (@L0AY_Kassem)
oncodaily.com/new-paper-aler…
#Cancer #Oncology #OncoDaily #Health #Medicine @CancerWorldmag
