Rochester MN
Joined July 2013
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Exciting news! Our research on "Surface-modified measles vaccines boosting neutralizing antibodies against Omicron and historical variants" is an Editor's Pick! Read it here: mBio journals.asm.org/doi/10.1128… #Vaccines #COVID19 #measles
Miguel Ángel Muñoz-Alía retweeted
Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles ... biorxiv.org/cgi/content/shor… #biorxiv_micrbio
If you are interested in our efforts on a new measles vaccine for early immunization of infants, stay tuned tomorrow, July 22 at #ASV2021. W36-7 at 3.30pm CT
Miguel Ángel Muñoz-Alía retweeted
1/ Here is a comprehensive review of the data on whether we need COVID BOOSTER SHOTS.
THE MOST IMPORTANT TAKEAWAY:
IF YOU HAVEN'T YET GOTTEN A COVID VACCINE, NOW'S THE TIME!
I'll put a Threadreader unroll at the end for those of you who find that more convenient to read/share.
Miguel Ángel Muñoz-Alía retweeted
*New paper alert*
I'm happy to share that our manuscript "Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2" is now published in @ScienceMagazine.
you can find it here: science.sciencemag.org/conte….
I did a long thread for the preprint a year ago :)
1/13 Up on BioRxiv: "Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro"! biorxiv.org/content/10.1101/…
For the most coherent story - read the paper. If you want to know how it ACTUALLY came about, read this thread :)
Miguel Ángel Muñoz-Alía retweeted
Just published @CellCellPress report on the Delta variant's immune evasion property:
—Less than Beta (good!)
—Vaccines should hold up (as effectiveness data supports)
—Prior covid with beta or gamma variants susceptible to reinfection by delta
cell.com/cell/fulltext/S0092…
Miguel Ángel Muñoz-Alía retweeted
"The fact it has happened twice in 18 months, two lineages (Alpha and then Delta) each 50% more transmissible is a phenomenal amount of change"—@ArisKatzourakis
bbc.com/news/health-57431420
by @JamesTGallagher @bbchealth
Miguel Ángel Muñoz-Alía retweeted
Not only do we have vaccines that can prevent covid infections from all variants, but we also have monoclonal antibodies that can protect vs/treat all of the variants that have emerged to date cell.com/cell/fulltext/S0092… New @CellCellPress
Absolutely delighted about #TWiV featuring our work on the constraints on measles antigenic evolution. Shout out to @jbloom_lab, @CellRepMed and @isabelgoldm for also giving visibility to our work.
On the latest #TWiV spillovers of porcine and canine #coronaviruses into humans in Haiti and Malaysia, how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on viral glycoproteins bit.ly/3fe9sh4
Miguel Ángel Muñoz-Alía retweeted
Now @MAMdayIndayOut has completed the picture with a new study in @CellRepMed showing that measles polyclonal antibodies have very broad activity, such that no single (or even double or triple) mutant has much reduction in neutralization (cell.com/cell-reports-medici…). (11/n)
Miguel Ángel Muñoz-Alía retweeted
We've written a perspective on a new study by @MAMdayIndayOut that helps explain why some viruses (measles) don't evolve to escape immunity but others (influenza) do. Provides some clues relevant to future for #SARSCoV2 as well: cell.com/cell-reports-medici…
Here is a recap: (1/n)
Miguel Ángel Muñoz-Alía retweeted
Hello, please find the unroll here: We've written a perspective on a new study by @MAMdayIndayOut that… threadreaderapp.com/thread/1… Share this if you think it's interesting. 🤖
Miguel Ángel Muñoz-Alía retweeted
Live-attenuated measles virus (MeV) remains antigenically monotypic. Escape from serum neutralization requires elimination of at least 5 co-dominant antigenic sites in the Hemagglutinin (H)-glycoprotein. Emergence of new serotypes is highly unlikely. @MayoClinic @MAMdayIndayOut
Miguel Ángel Muñoz-Alía retweeted
Mayo Clinic scientists conclude in new publication that there is a near-zero probability for the natural emergence of a new measles virus capable of evading vaccine-induced immunity. Read more: mayocl.in/3sHD3UD
Researchers Clarify Why Measles Doesn’t Evolve to Escape Immunity discoverysedge.mayo.edu/2021… @Discovery's Edge @CellRepMed
