NK Escareño (@NKcellMX) header
NK Escareño (@NKcellMX) profile picture

NK Escareño

@NKcellMX

Immunologist into cell death & NK cells @MPIbp #MembraneDynamics #Optogenetics #NLRP3 🇲🇽

 Frankfurt am Main, Germany
Joined April 2014
  • Tweets1.8K
  • Following5K
  • Followers671
1Media
Photo by NK Escareño (@NKcellMX)
NK Escareño retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 28
Replying to @biorxivpreprint
@biorxivpreprint Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity biorxiv.org/content/10.64898… @at_Mitralab @univ_lille @inserm
Image from Waggoner Lab (@LabWaggoner)
5
26
1,729
New online! A nanoscale map of the human cell surface proteome reveals spatial and functional organization dlvr.​it/TW5N1k
Image from NatureStructMolBiol (@NatureSMB)
7
1
32
2,388
NK Escareño retweeted
Science Signaling (@scisignal) profile picture
Science Signaling@scisignalOct 25
How do inflammasomes drive CAPS? A mass cytometry analysis decrypts how #NLRP3 mutations in patient neutrophils trigger the clustering of gasdermin D and E at the plasma membrane, leading to #pyroptosis and the release of IL-1-beta. @UCSanDiego scim.ag/3THE7dU
A microscopic view of three white blood cells with a vivid blue nucleus surrounded by purple and yellow granules, set against a black background.

ALT A microscopic view of three white blood cells with a vivid blue nucleus surrounded by purple and yellow granules, set against a black background.

1
11
1
22
1,460
NK Escareño retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 19
Dimeric granzyme-A mediates the specific recognition and cleavage of full-length GSDMB @NatureComms nature.com/articles/s41467-0…
Image from Waggoner Lab (@LabWaggoner)
6
13
1,309
NK Escareño retweeted
Casanova Lab (@casanova_lab) profile picture
Casanova Lab@casanova_labOct 24
A surprising NFKB1 mutation: NFKB1 truncation–associated recurrent, sterile inflammation effectively treated with IL-1β blockade rupress.org/jhi/article/3/1/…
NFKB1 truncation–associated recurrent, sterile inflammation effectively treated with IL-1β blockade

NFKB1 truncation–associated recurrent, sterile inflammation effectively treated with IL-1β blockade

Recurrent, sterile inflammatory responses to surgery and trauma in a patient with a heterozygous, truncating NFKB1 variant are described. This case illustr

rupress.org
6
21
1,769
NK Escareño retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 23
Antigen-independent IgM BCR signaling intrinsically limits human IgM plasma cell differentiation, survival, and in vivo persistence by elevating basal calcium flux and restraining IRF4 and BLIMP1 induction rupress.org/jem/article-abst… @JExpMed @seattlechildren
Image from Waggoner Lab (@LabWaggoner)
14
33
1,825
EVウイルス由来の膜タンパク質『LMP1』を腫瘍細胞に導入するとT細胞に攻撃されやすくなるメカニズムを応用した治療法とかめっちゃ面白いやん！🤩 あ、もちろんLMP1ペプチドがMHCに提示されてとかいうオチじゃないですよ🤣 LMP1が腫瘍細胞でのMHC-I、CD80発現を大きく上昇させて、それを認識してCD8陽性T細胞が攻撃するって流れですね で、そのメカニズムを詳しく調べると 腫瘍細胞の転写因子である ✅Spi-B → CD80発現を誘導 ✅IRF1 → MHC-I発現を誘導 していることを発見🎊そうなると次は 「あれ、MHC-Iは何を提示してるん？」 ってなりますよね🤔 そこは腫瘍細胞も正常細胞も持つ 『内在性レトロウイルス由来ペプチド』 を提示して、CD8陽性T細胞がそれを目印に攻撃するわけです🥊 ちなみに、この内在性レトロウイルス由来遺伝子の一部はSpi-Bに発現誘導されます！ 最終的にはSpi-B＋IRF1を腫瘍細胞に導入って流れになるけど、個人的には一部の腫瘍に導入されただけで周りの導入されていない腫瘍も縮小するのは面白いですね👀 あとは、正常細胞にSpi-B＋IRF1を導入してもT細胞に攻撃されるのか気になるし、もしそうなら腫瘍特異的な遺伝子導入法が必要ですかね🧬
Image from 島らっきょう大好きバナナさん🍌 (@SimarakyoBanana)
日本の研究.comニュース (@rjp_news) profile picture日本の研究.comニュース
@rjp_newsOct 23
【注目プレスリリース】隠れたがんを免疫に見つけさせる方法を発見 －EBウイルスの仕組みを応用した新たながん治療法の可能性－ / 広島大学 research-er.jp/articles/view…
【プレスリリース】隠れたがんを免疫に見つけさせる方法を発見 －EBウイルスの仕組みを応用した新たながん治療法の可能性－ | 日本の研究.com

【プレスリリース】隠れたがんを免疫に見つけさせる方法を発見 －EBウイルスの仕組みを応用した新たながん治療法の可能性－ | 日本の研究.com

2026.10.23 広島大学 プレスリリース 【本研究成果のポイント】EBウイルスのLMP1というタンパク質(※1)をがん細胞に作らせると、がん細胞を攻撃するキラーT細胞(※2)の働きが高まり、がんの増殖を抑えられることを明らかにしました。「Spi-B」と「IRF1」という2つのタンパク質をがん細...

research-er.jp
1
8
54
3,315
NK Escareño retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 23
A granzyme-independent function of perforin as a direct executioner of cancer cell death through ferroptosis @CellCellPress cell.com/cell/fulltext/S0092… @umichmedicine @harvardmed @barrosolab @AlbanyMed #Zou #Lieberman
Image from Waggoner Lab (@LabWaggoner)
21
2
61
4,039
NK Escareño retweeted
Bryson Lab (@TheBrysonLab) profile picture
Bryson Lab@TheBrysonLabOct 23
Antigen discovery and TB vax friends 🧵 We set out to find more Mtb peptides presented on MHC-I. We had a strong biological prior, a high-throughput binding screen, and a very sensitive targeted MS assay. Of 286 candidates, we detected 2. biorxiv.org/content/10.64898…
Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I

Multiple bottlenecks constrain presentation of Mycobacterium tuberculosis antigens on MHC class I

CD8+ T cell recognition of pathogen-derived peptides presented on major histocompatibility complex class I (MHC-I) contributes to protective immunity against intracellular pathogens like Mycobacter...

biorxiv.org
6
12
1
51
3,980
NK Escareño retweeted
Magnus Bauer (@kinasekid) profile picture
Magnus Bauer@kinasekidOct 18
Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 nature.com/articles/s41586-0…
Image from Magnus Bauer (@kinasekid)
3
55
6
319
21,689
NK Escareño retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerOct 13
EBV hijacks the metabolic function of CD73 to resist the antitumor function of NK cells nature.com/articles/s41698-0…
Image from Waggoner Lab (@LabWaggoner)
1
10
39
2,255
Design and characterization of peptide-responsive biosensors doi.org/10.64898/2026.10.03.…
2
18
85
7,484
NK Escareño retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopolOct 11
A seminal paper on aging of our immune system was just published. From study of over 12 million single-cells in 8 cohorts, >2,600 individuals, ranging in age from 18 to 98. Yielding a practical blood test. And much more. A Tale of Two T cells In the new Ground Truths
Image from Eric Topol (@EricTopol)
21
82
2
440
45,727
NK Escareño retweeted
Stanford University (@Stanford) profile picture
Stanford University
@StanfordOct 9
A @bioe_stanford study reveals how changes in DNA packaging can help immune cells burst, shedding light on a defense process implicated in autoimmune diseases. news.stanford.edu/stories/20…
What makes an immune cell pop

What makes an immune cell pop

A Stanford study reveals how changes in DNA packaging can help immune cells burst, shedding light on a defense process implicated in autoimmune diseases.

news.stanford.edu
5
26
1
142
17,108
NK Escareño retweeted
Keita Masui (@keita_masui) profile picture
Keita Masui
@keita_masuiOct 8
これはヤバい。鳥類由来のR2レトロトランスポゾンを工学的に改変し、ヒト細胞でオールRNA媒介による標的DNA組み込みを実現。ウイルスベクター不要の次世代遺伝子治療プラットフォームになり得る技術で、デリバリー問題を抱える日本の遺伝子治療開発にも大きな示唆。 nature.com/articles/s41587-0… #遺伝子治療 #RNA #BioTech @NatureBiotech
Discovery and engineering of avian R2 retrotransposons for all-RNA-mediated targeted DNA integrat...

Discovery and engineering of avian R2 retrotransposons for all-RNA-mediated targeted DNA integrat...

Nature Biotechnology - Engineered retrotransposons enable site-specific DNA integration into human cells.

nature.com
14
2
54
7,203
NK Escareño retweeted
Molecular Cell (@MolecularCell) profile picture
Molecular Cell@MolecularCellOct 6
Online Now: DNASE1L3 maintains homeostatic levels of mitochondrial DNA on the mammalian cell surface dlvr.​it/TVpC9L
Image from Molecular Cell (@MolecularCell)
1
9
32
4,615
NK Escareño retweeted
Benetton (@benenen12345) profile picture
Benetton@benenen12345Oct 5
翻訳語のタンパク質の配列を編集する タンパク質を繋ぎ変えるインテインを分離して目的タンパク質に繋ぎ、翻訳語に配列を編集できる系を確立 ルシフェラーゼやmNeonGreen、Creなど様々なタンパク質で高い編集効率に基づく活性制御を実証した #BNTNJC biorxiv.org/content/10.64898…
Image from Benetton (@benenen12345)
1
7
52
4,314
NK Escareño retweeted
Joe Sabatino (@jsabatino37) profile picture
Joe Sabatino@jsabatino37Oct 5
The trogocytosis plot of T cell-B cell interactions thickens! T–B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclerosis pnas.org/doi/10.1073/pnas.26…
T–B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclero...

T–B interactions yield CD3+ B cells and CD20+ T cells with pathogenic features in multiple sclero...

Classically, B and T cells are differentiated by their mutually exclusive expression of surface markers such as CD3 and CD20, but it is now establi...

pnas.org
1
33
4
130
16,722
NK Escareño retweeted
J Cell Science (@J_Cell_Sci) profile picture
J Cell Science@J_Cell_SciOct 1
A new lamin assembly assay using Xenopus egg extracts @RossTAPedersen, @ZhengYixian @CarnegieScience @CarnegieDevBio and colleagues reconstitute lamin assembly on nuclear pore complex-containing membranes. Highlight: journals.biologists.com/jcs/… Article: journals.biologists.com/jcs/…
Figure showing that lamin-B3 assembly occurs on annulate lamellae in the absence of nuclei.

ALT Figure showing that lamin-B3 assembly occurs on annulate lamellae in the absence of nuclei.

1
5
1
11
1,474
マジ謎だったけどmechanobiology的な話だったのか...!
島らっきょう大好きバナナさん🍌 (@SimarakyoBanana) profile picture島らっきょう大好きバナナさん🍌
@SimarakyoBananaSep 30
へぇー、心臓で癌ができにくい理由とか考えたこともなかった😳 言われてみれば心臓は血流も多いから、原発癌だけじゃなくて転移癌も多そうなのに不思議よね🤔 この論文ではこの現象を、下記のようなメカニズムで説明しています↓ 1️⃣心臓の収縮や圧負荷による機械刺激が癌細胞に掛かる 2️⃣機械刺激を感知したNesprin-2を介してヒストンのメチル化（H3K9me3）が低下 3️⃣クロマチン構造が緩んで細胞周期停止などに関わる遺伝子の転写が向上 4️⃣癌細胞の増殖抑制 ちなみにこのメカニズムの証明として、 🔹マウスの心臓、肝臓、骨格筋などでKRAS G12Dとp53欠失を同時に誘導しても心臓には腫瘍が形成されないこと 🔹マウスで心臓から機械的負荷を取り除くと癌細胞が急速に増殖すること 🔹同一患者の心臓転移と心臓外病変を比較して心臓転移癌ではH3K9me3が低下していること 🔹H3K9の脱メチル化を抑制すると癌細胞が増殖すること 🔹Nesprin-2を抑制すると機械刺激があっても癌細胞が増殖すること を確認していますね🫀 こーゆう発見から新しいメカニズムの薬の発想って生まれるから、読んでてワクワクしますよね🤩
Image from 島らっきょう大好きバナナさん🍌 (@SimarakyoBanana)
1
1
6
797
Load more