Multidisciplinary team working together to develop, validate, and implement liquid biopsies to improve the lives of patients with prostate cancer.
Joined October 2016
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.@PCF_SELECT #cfDNA assay detects #allelicimbalance (e.g. BRCA2, ATM, PTEN) in #prostatecancer plasma with high sensitivity. Consortium of @FrancescaBZNY @AttardLab @mishabeltran @ResearchWyatt @MarkARubin1 labs and teams! @PCF_Science @AIRC_it @CR_UK academic.oup.com/narcancer/a…
PCF_SELECT retweeted
The #IPCS26 @APCCC_Lugano with wonderful data in #prostatecancer
1️⃣Liquid biopsies
2️⃣Neuroendlcrine differentiation
🔵Epigenetics
🔴NEMO: Neuroendocrine monitoring panel
🟢Targeting methylation
@Silke_Gillessen @mishabeltran @DanaFarberNews @RodRogSan @feresparza06
PCF_SELECT retweeted
Clonal hematopoiesis (CH) in the @ANZUPtrials #TheraP study @ASCO #ASCO25 presented by Asli Munzur
■ ¹⁷⁷Lu-PSMA-617: higher incidence of emergent CH compared to cabazitaxel chemotherapy
■ Most new clonal hematopoiesis mutations ¹⁷⁷Lu-PSMA-617 fall in DNA damage repair response genes PPM1D, TP53, ATM, and CHEK2.
■ Clinical significance unclear but may become more relevant as radioligand therapy moves into earlier lines of treatment
@ResearchWyatt @AzadOncology
PCF_SELECT retweeted
Quick overview of news in Prostate Cancer from Esmo with @Ecastromarcos @AttardLab and Axel Heidenreich
Please follow ecancer.org/en/video/12526-b…
PCF_SELECT retweeted
Just out today in @jclinicalinvest 🚀
mHSPC is not one disease, but a kaleidoscope of biological states. We highlight what we know — and the key gaps that remain — on the road to precision medicine✨
Led by my mentor @mishabeltran 🙌
#ProstateCancer #mHSPC #PrecisionOncology
Exploring the biology of metastatic hormone-sensitive #ProstateCancer: on the road to precision medicine
In this Review, Alice Bernard-Tessier & Himisha Beltran @mishabeltran @danafarber discuss the underlying biology in mHSPC and highlight current knowledge gaps: doi.org/10.1172/JCI200920
PCF_SELECT retweeted
Excited to share our new paper @NatureComms in collaboration with @RickmanLab, led by #RichaSingh @WeillCornell and @Bajji @DanaFarber #BeltranLab
New research published in @NatureComms provides critical mechanistic insights into how prostate cancer becomes resistant to treatment, uncovering how two key epigenetic mechanisms - DNA methylation and EZH2 activity - work together to drive transformation to a more aggressive form of the disease, neuroendocrine prostate cancer. @DanaFarber @bajji @mishabeltran
Read more: bit.ly/4sk61bg
PCF_SELECT retweeted
Understanding ctDNA technology applications for cancer detection and characterization. @ResearchWyatt @VanProstateCtr joins @UroDocAsh @MDAndersonNews to break down the fundamentals of cell-free DNA and how ctDNA represents the tumor-derived portion of these fragments in the bloodstream. #WatchNow on UroToday > bit.ly/42EeUm4
PCF_SELECT retweeted
Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer @NatureComms
rdcu.be/euijO
Team science led by Kei Mizuno #BeltranLab @DanaFarber_GU @PCF_Science
PCF_SELECT retweeted
Favorite study!
Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies.
Kudos: Blerta Stringa,
@Paola_Gasperini, Alessandro Alaimo, and
@LunardiLabCIBIO (co-last a!)
@NimaSharifiMD
doi.org/10.1158/2159-8290.CD…
@UniTrento
ALT Germline-somatic tandems increase cell fitness, favoring cell transformation. This type of germline-somatic tandem is detectable through association studies testing hypothesis-constrained germline variants and molecular subclasses of human tumors.
PCF_SELECT retweeted
Stunning research from @EdmondMKwan on ctDNA in theranostics:
🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy
⚠️PTEN alterations linked to worse outcomes on cabazitaxel
🧪ATM defects tied to favorable PSMA-617 results
🩻PET quantitative biomarkers (SUVmean) are additive
🌟We identify new candidate biomarkers for ¹⁷⁷Lu–PSMA-617 selection and ultimately expand the mCRPC predictive biomarker repertoire
Online at @NatureMedicine
nature.com/articles/s41591-0…
@ANZUPtrials #TheraP @MovemberAUS @PCFA
Support by @PCF_Science Challenge Award
@ResearchWyatt @AzadOncology @Prof_IanD
PCF_SELECT retweeted
Elegant presentation from @ResearchWyatt on the evolution of ctDNA detection and characterization! Session chaired by @DanaFarber_GU's @OncoBellmunt and @BartsECMC 's @b_szabados
#GU25 @ASCO @OncoAlert @OncLive
PCF_SELECT retweeted
Exciting work ahead on Large #Oncosomes at the @UniTrento @CIBIO_UniTrento with our team #DemichelisLab, Dolores Di Vizio @doldivizio at @CedarsSinai and Shannon Stott @svploeg at @MGH_RI funded by the @theNCI #PLUS
This Post is from an account that no longer exists. Learn more
PCF_SELECT retweeted
Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest
by @GiuliaFracassi_ an @AIRC_it fellowship awardee
and @FraLo05 a @PCF_Science YIA
Collaborators: @quimmateo @FdAdF66
Relevant to #prostatecancer and beyond. Download it!
jci.org/articles/view/179393
🚨 New Preprint Alert! 🚨
I’m thrilled to share our latest study now online on JCI:
CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer.
🔬 Check out the preprint here: doi.org/10.1172/JCI179393
Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento @CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker.
Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR.
#ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine
PCF_SELECT retweeted
PROSTATE Paper 2
Franseschini et al. developed a targeted DNA methylation assay for the detection of neuroendocrine prostate cancer using plasma cell-free DNA with an AUC > 0.93. Their assay also quantifies tumor content and offers a phenotype evidence score, which reflects various CRPC phenotypes. @CD_AACR . Lead our own @mishabeltran @DanaFarber_GU
aacrjournals.org/cancerdisco…
PCF_SELECT retweeted
Heartbroken💔we lost Dr. Felix Feng— close friend, selfless collaborator, brilliant scientist & a man who saved many prostate cancer lives with a triad of generosity, kindness, & teamwork. We miss you @felixfengmd --too early my friend.
To all: please consider supporting this @ASTRO_org @AmericanCancer award in Felix name:
donate.cancer.org/g/tjjfqwdn…?
PCF_SELECT retweeted
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
PCF_SELECT retweeted
The last time Felix stood on our stage, after a beautiful talk by @mishabeltran & intro by @AminaZoubeidi
💔💔💔
vimeo.com/1037583309/b7dd022…
Felix was the best of us. I'm heartbroken by his passing.💔His spirit of generosity, kindness, humility, his humor, intelligence & scientific acumen - you made us better scientists & better people, Felix. Love & miss you always. My deepest condolences to @MaryFengMD & family.🙏♥️
PCF_SELECT retweeted
A tremendous loss for the cancer scientific community. @felixfengmd truly was one of the very best. I feel fortunate to have had the chance to meet him. This is heartbreaking but I want to remember him with the smile that always lit up his face 💔@MaryFengMD 💔
PCF_SELECT retweeted
Exciting news! Dr. Alex Wyatt, a senior research scientist at the Vancouver Prostate Centre, is now the scientific director for the Clinical Cancer Genomics Program at BC Cancer. @ResearchWyatt
prostatecentre.com/news/dr-a…
PCF_SELECT retweeted
@mishabeltran sharing DLL3 PET/CT images including correlation with PSMA and FDG from @morr316 @PCF_Science
TACTICAL grant
#ESMO24 @myESMO
