Sam Lord (@SamLord98) profile picture

Sam Lord

@SamLord98

Research Associate | Proteomics Core Facility | CRUK

 Cambridge, England
Joined January 2020
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Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)
Excited to share our latest review in the Journal of Cachexia, Sarcopenia and Muscle @JCSM_cachexia. Here we show how mass spectrometry can be used to profile ubiquitin signalling in skeletal muscle. Great team effort with @HarveyEJohnston and @SamantLab onlinelibrary.wiley.com/doi/…
Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle

Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle

Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged,...

onlinelibrary.wiley.com
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News & Views from @DemichevLab and @LrSinn: Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell. nature.com/articles/s41592-0…
Entering the era of deep single-cell proteomics

Entering the era of deep single-cell proteomics

Nature Methods - Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.

nature.com
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Really grateful to have been given the opportunity to present at another @physoc conference. Great to catch up with colleagues and meet new researchers in the muscle field. Nice bonus to have been chosen for the ECR oral communication award 😀
The Physiological Society (@PhySoc) profile pictureThe Physiological Society
@PhySoc6 Sep 2024
🎉 Many congratulations to the #EarlyCareerResearchers competition winners! The winners & runners ups for the Flash Talks & Oral Communications were announced at our #MuscleLoss meeting @UniofExeter. Well done to all the awardees and presenters, see details below 🧵 1/3
Image from The Physiological Society (@PhySoc)
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Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus... academic.oup.com/ageing/arti…
Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type...

Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type...

AbstractBackground. The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test

academic.oup.com
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Really enjoyed learning more about Genomics, Proteomics and Biodata. Always a bonus to showcase some of our work on the ageing muscle proteome and engage in some great discussions #FOG2024
Image from Sam Lord (@SamLord98)
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Happy to see my first PhD project now published! Here we studied the mechanisms of ubiquitylation utilised by a family of muscle-specific enzymes known as MuRF E3 ligases. doi.org/10.1016/j.bbrep.2023…
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Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at @Cell_Metabolism ! An entirely new way in which mTOR senses AA deficiency cell.com/cell-metabolism/ful… Thanks @pak_heidi for pointing out this one.

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Ge et al. unravel a novel mechanism of amino acid sensing by mTORC1, in which amino acid depletion-caused accumulation of uncharged tRNAs stimulates GCN2 to phosphorylate FBXO22, which in turn...

cell.com
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We’re excited to plant the seed of a UK-wide network bringing together researchers at all levels with an interest in #proteostasis #ProteinQualityControl. 1/4 proteostasisuk.co.uk/
Screen capture of the ProteostasisUK website. Text reads: ProteostasisUK: bringing the proteostasis community in the UK together, uniting researchers across the fields of protein folding, quality control, aggregation, degradation and beyond. Button reads: Shape the Network.

ALT Screen capture of the ProteostasisUK website. Text reads: ProteostasisUK: bringing the proteostasis community in the UK together, uniting researchers across the fields of protein folding, quality control, aggregation, degradation and beyond. Button reads: Shape the Network.

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With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.
Image from Kylie Walters (she/her) (@kyliejwalters)
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Great to have been part of this larger project! I’m now very intrigued about the Leloir pathway and studying it further with our new cell line 🧫
Gareth Wallis (@gareth_wallis) profile pictureGareth Wallis@gareth_wallis18 Oct 2023
Replying to @gareth_wallis
Lots of questions here around if the circulating galactose is/was used for glycogen synthesis. We don't have the answers. Our exploratory analysis by @alex_seabright @SamLord98 and @RitaCivil saw human skeletal muscle expresses Leloir pathway enzymes at gene and protein level 6/7
Image from Gareth Wallis (@gareth_wallis)
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Global analysis of ubiquitylation site occupancy, revealing how this effects ubiquitin turnover rate (DUBs) and signalling (proteasomal or non-proteasomal). biorxiv.org/content/10.1101/…
A global, integrated view of the ubiquitylation site occupancy and dynamics

A global, integrated view of the ubiquitylation site occupancy and dynamics

Ubiquitylation regulates virtually all proteins and biological processes in a cell. However, the global site-specific occupancy (stoichiometry) and turnover rate of ubiquitylation have never been...

biorxiv.org
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New paper out! Bone🦴 markers responses to running 🏃‍♂️ @Sale_ExNut, @ElliottSale, Phil Atherton, Ian Varley, @Liv65761161, @PaulSwinton9, and @eimeardol sportsmedicine-open.springer…

P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A...

Sports Medicine - Open - Circulating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise are not clear. This study aimed to...

link.springer.com
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Some snapshots from our poster session today #HMAC2023 ⁦@ARThealthyaging⁩ ⁦@LJMUSportSci⁩ ⁦@physoc⁩ ⁦@BiochemSoc⁩
Image from Jatin Burniston (@ExercProteomics)
Image from Jatin Burniston (@ExercProteomics)
Image from Jatin Burniston (@ExercProteomics)
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One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles | buff.ly/3rb8efi #proteomics
Image from Pastel BioScience (@PastelBio)
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Beyond Myosin Heavy Chains: Ribosomal Specialization Drives Human Skeletal Muscle Fiber Heterogeneity biorxiv.org/cgi/content/shor… #biorxiv_physio
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Now online. I really liked this chat!: Muscle atrophy with aging mainly protein breakdown New thinking on muscle nuclei/satellite cells Drugs not as good as exercise for healthspan Thanks (no Twitter) Benjamin! Spotify (shorturl.at/cDGK5), Apple Podcasts, YouTube etc
Image from Inside Exercise (@inside_exercise)
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Great time competing in my first Racketlon competition, certainly more to come…
UK Racketlon (@UKracketlon) profile pictureUK Racketlon@UKracketlon10 Jul 2023
Well done to Jordan Marcus (Men's B) and Saul Abbiss (Men's C) who both won their first UK Racketlon titles at the 2023 York Open 👏
Image from UK Racketlon (@UKracketlon)
Image from UK Racketlon (@UKracketlon)
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Glad you enjoyed it 😊. Thanks @physoc for the opportunity to present this work, the feedback has been great. #Physiology2023
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Really interesting panel discussion about the process of publishing. Great to hear honest views from peer reviewers and editors #Physiology2023
Image from Sam Lord (@SamLord98)
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🥳Final countdown! @physoc annual conference starts Monday morning. Looking forward to joining hundreds of physiologists from 40 countries in Harrogate to discuss the latest science & forge new collaborations. See you there! physoc.org/events/physiology…
Physiology 2023

Physiology 2023

The Physiological Society's annual conference is The Society’s flagship event. Hear the latest in physiology with first class science & unmissable networking opportunities

physoc.org
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