Sam Lord (@SamLord98) profile picture

Sam Lord

@SamLord98

Research Associate | Proteomics Core Facility | CRUK

 Cambridge, England
Joined January 2020
  • Tweets80
  • Following222
  • Followers165
7Media
Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)Photo by Sam Lord (@SamLord98)
News & Views from @DemichevLab and @LrSinn: Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell. nature.com/articles/s41592-0…
Entering the era of deep single-cell proteomics

Entering the era of deep single-cell proteomics

Nature Methods - Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.

nature.com
1
8
1
26
5,161
Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus... academic.oup.com/ageing/arti…
Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type...

Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type...

AbstractBackground. The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test

academic.oup.com
1
3
13
1,035
Really cool new paper "The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency" at @Cell_Metabolism ! An entirely new way in which mTOR senses AA deficiency cell.com/cell-metabolism/ful… Thanks @pak_heidi for pointing out this one.
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Ge et al. unravel a novel mechanism of amino acid sensing by mTORC1, in which amino acid depletion-caused accumulation of uncharged tRNAs stimulates GCN2 to phosphorylate FBXO22, which in turn...

cell.com
8
38
5,535
We’re excited to plant the seed of a UK-wide network bringing together researchers at all levels with an interest in #proteostasis #ProteinQualityControl. 1/4 proteostasisuk.co.uk/
Screen capture of the ProteostasisUK website. Text reads: ProteostasisUK: bringing the proteostasis community in the UK together, uniting researchers across the fields of protein folding, quality control, aggregation, degradation and beyond. Button reads: Shape the Network.

ALT Screen capture of the ProteostasisUK website. Text reads: ProteostasisUK: bringing the proteostasis community in the UK together, uniting researchers across the fields of protein folding, quality control, aggregation, degradation and beyond. Button reads: Shape the Network.

2
21
7
58
20,979
With a fixed typo, I re-invite you to come chat Ub & Targeted Protein Degradation with our welcoming community at the @FASEBorg #UBPSRC where full days of exciting science with joyful interactions will be capped by nightly fireworks over the natural wonder of Niagara Falls.
Image from Kylie Walters (she/her) (@kyliejwalters)
1
12
1
41
7,182
New paper out! Bone🦴 markers responses to running 🏃‍♂️ @Sale_ExNut, @ElliottSale, Phil Atherton, Ian Varley, @Liv65761161, @PaulSwinton9, and @eimeardol sportsmedicine-open.springer…

P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A...

Sports Medicine - Open - Circulating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise are not clear. This study aimed to...

link.springer.com
8
29
2,758
Some snapshots from our poster session today #HMAC2023 ⁦@ARThealthyaging⁩ ⁦@LJMUSportSci⁩ ⁦@physoc⁩ ⁦@BiochemSoc⁩
Image from Jatin Burniston (@ExercProteomics)
Image from Jatin Burniston (@ExercProteomics)
Image from Jatin Burniston (@ExercProteomics)
3
10
806
One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles | buff.ly/3rb8efi #proteomics
Image from Pastel BioScience (@PastelBio)
10
22
2,703
Beyond Myosin Heavy Chains: Ribosomal Specialization Drives Human Skeletal Muscle Fiber Heterogeneity biorxiv.org/cgi/content/shor… #biorxiv_physio
3
10
764
Now online. I really liked this chat!: Muscle atrophy with aging mainly protein breakdown New thinking on muscle nuclei/satellite cells Drugs not as good as exercise for healthspan Thanks (no Twitter) Benjamin! Spotify (shorturl.at/cDGK5), Apple Podcasts, YouTube etc
Image from Inside Exercise (@inside_exercise)
3
8
2
41
6,700
🥳Final countdown! @physoc annual conference starts Monday morning. Looking forward to joining hundreds of physiologists from 40 countries in Harrogate to discuss the latest science & forge new collaborations. See you there! physoc.org/events/physiology…
Physiology 2023

Physiology 2023

The Physiological Society's annual conference is The Society’s flagship event. Hear the latest in physiology with first class science & unmissable networking opportunities

physoc.org
3
6
29
2,784
Tissue-specific protein profiles in #aging C57BL/6 mice @CellReports cell.com/cell-reports/fullte…
Global and tissue-specific aging effects on murine proteomes

Global and tissue-specific aging effects on murine proteomes

Organismal aging drives pleiotropic changes in tissue and cellular homeostasis. By quantifying the proteomes of 10 tissues, including three brain sections, in aging mice, Keele et al. explore the...

cell.com
37
1
117
19,347
The day has come where ubiquitin/TPD is featured at Lorne!! Ubiquitin friends - if you’re looking for a reason to visit Melbourne and drive the beautiful great ocean road - this is it 🇦🇺🦘❤️ 2024 @LorneProteins will be a goodie!
Image from Katherine A Donovan (@kdonovan1008)
1
9
40
5,263
Our 5-day international PhD course is underway! We have an excellent lineup of world renowned international speakers as well as 29 rising star PhD students from 8 countries around the globe! 🤩 #MuscleCPH2023 @NEXSKU
Image from Molecular Physiology UCPH (@MolecularUCPH)
9
48
4,307
Chronic Inflammation and the Hallmarks of Aging… sciencedirect.com/science/ar…
Image from Christoph Burch (@ChristophBurch)
3
103
1
303
35,646
PREPRINT: "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training." HUGE team effort, and awesome collab w/stellar @seer_bio team. #myotwitter folks should check them out! biorxiv.org/content/10.1101/…
A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures...

A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures...

We examined the myofibrillar (MyoF) and non-myofibrillar (non-MyoF) proteomic profiles of the vastus lateralis (VL) muscle of younger (Y, 22±2 years old; n=5) and middle-aged participants (MA, 56±8...

biorxiv.org
2
24
1
74
9,529
Don't miss out on your opportunity to enjoy a warm welcome with first class science and exciting Prize Lectures at our annual conference #Physiology2023, all in the historic Victorian spa town of Harrogate. Register by 19 June 🔗 physoc.org/events/physiology…
Physiology 2023

Physiology 2023

The Physiological Society's annual conference is The Society’s flagship event. Hear the latest in physiology with first class science & unmissable networking opportunities

physoc.org
Harrogate Convention Centre (@HgtConventions) profile pictureHarrogate Convention Centre@HgtConventions5 Jun 2023
In just over a month we will welcome the global community of physiologists to #Harrogate for their annual conference. @physoc #Physiology2023 #conference #conferencevenue #hcc #eventprofs
Image from Harrogate Convention Centre (@HgtConventions)
5
8
3,293
‼️A guide to mass spec proteomics for beginners! Peer-reviewed and published AND OPEN ACCESS FOR THE NEXT SIX MONTHS! Answers to the questions: -How does MS proteomics work? -How do I perform a proteomic experiment? -Where can I learn more? #teammassspec pubs.acs.org/doi/10.1021/acs…
An Introduction to Mass Spectrometry-Based Proteomics

An Introduction to Mass Spectrometry-Based Proteomics

Abstract. Mass spectrometry is unmatched in its versatility for studying practically any aspect of the proteome. Because the foundations of mass spectromet

pubs.acs.org
13
190
8
730
114,271
Mass spectrometry-based proteomics approaches to interrogate skeletal muscle adaptations to exercise | #myotwitter pubmed.ncbi.nlm.nih.gov/3697…
Mass spectrometry-based proteomics approaches to interrogate skeletal muscle adaptations to...

Mass spectrometry-based proteomics approaches to interrogate skeletal muscle adaptations to...

Acute exercise and chronic exercise training elicit beneficial whole-body changes in physiology that ultimately depend on profound alterations to the dynamics of tissue-specific proteins. Since the...

pubmed.ncbi.nlm.nih.gov
7
23
3,821
We used #plasmaproteomics to look for biomarkers of #muscleatrophy caused by #bedrest. Our paper with the support of Italian Space Agency @ASI_spazio and our coworkers in the MARS-PRE project is now online. onlinelibrary.wiley.com/doi/…
Image from Matthias Mann Lab (@labs_mann)
11
2
66
9,060
Load more