Ajai Pathak retweeted
Bird songs share surprising similarities with human music and speech, according to a large-scale study comparing vocalizations across hundreds of bird species and dozens of human languages.
The findings in Science suggest that these similarities may arise partly from shared biological mechanisms, rather than vocal learning ability alone.
Learn more: scim.ag/4ikVRUr
"Nothing is free in biology.” Chronic stress reshapes how the brain allocates a limited energy budget—potentially shaping thoughts, emotions, behavior, and long-term mental health. A compelling framework for understanding stress as an energy-allocation problem. 🧠⚡ – at Tartumaa, Eesti
Today on TSEE, we share a new model that connects the body's energy demand, how stress (dis)allocates energy, and how this is related to our behaviors, thoughts, emotions, and mental health.
Guest writer @sequencemyneuro from our group provides an overview of the Allostatic Triage model of Psychopathology (ATP Model). This model helps explain how our brains manage the body's limited energy budget. And how stress may contribute to the development of disease symptoms over time.
Nothing is free in biology. So stress costs energy. Chronic stress changes how our energy flows and is distributed. We now think that this leads to energy patterns that show up as thoughts, emotions, and behaviors that—over time—negatively impacts our mental and physical health. Parker's ATP Model provides a framework to understand how dynamic energy patterns shape our lives and our health.
tseenergy.substack.com/p/can…
Fascinating step toward drug-free metabolic care—an implant that clears excess glucose on demand could reshape how we manage obesity and type 2 diabetes. ⚡🩸
#Science #Diabetes #Obesity #MedTech
An implantable, wirelessly powered electronic device could offer a drug-free approach to managing the intertwined metabolic disorders of obesity and type 2 diabetes.
The device uses electrocatalysis to remove excess glucose from the bloodstream on demand.
Learn more in Science: scim.ag/47twScK
Ajai Pathak retweeted
We're unable to measure our immune system status in the clinic. But that is about to change.
Our @nature piece today, w/ @HugoAerts @nbirkbak @TsangLab
nature.com/articles/d41586-0…
Ajai Pathak retweeted
MATTER OF GREAT PRIDE FOR INDIAN SCIENCE!
Ashoke Sen becomes the first Indian to win the prestigious Oskar Klein Medal (2026), jointly awarded by Stockholm University and the Nobel Committee for Physics of the Royal Swedish Academy of Sciences for his pioneering work in String theory.
deccanherald.com/science/ben…
String theory gives a unified description of all matter and the forces between them based on the postulate that the elementary constituents of matter are tiny one dimensional (string-like) objects instead of point particles. Sen’s breakthrough work has shown that multiple string theories are all different versions of a single underlying theory.
Incidentally, I met Ashok Sen for the first time, when both of us were elected as FRS (Fellows of Royal Society) in 1998. Ashoke ( nominated by Stephen Hawking himself) was young 42 yrs and
I was an oldie - 55 yrs though!
What struck me was Ashoke’s incredible simplicity. His wife Sumathi Rao has reportedly said that Ashoke bought his first suit and needed some assistance to wear his first tie for that prestigious 1998 FRS ceremony in London, when one signs in the same book that Sir Isaac Newton has signed.
A film made on the life and work of Ashoke Sen, when we at the
H K Firodia Award in Science & Technology honoured him in 2005 in Pune, will inspire all our budding scientists - showing how science & simplicity goes together.
youtu.be/CoVc5cM5XlU?si=vQNQ…
We all feel so so proud Ashoke!
@PMOIndia @NITIAayog @PrinSciAdvOff @IndiaDST @CSIR_IND @ictstifr @PuneIntCentre @kvijayraghavan
Ajai Pathak retweeted
Genomic structural variations distinguishing archaic and modern humans are associated with neurodevelopment: iScience cell.com/iscience/fulltext/S…
Ajai Pathak retweeted
Seeing a lot of growing raw hatred against India, Indians, Hindus, Indian-Americans, etc. for no reason.
Would be happy to have anyone who feels that hatred quietly unfollow me. Simple. Clean. Thanks in advance.
Promising finding. A natural defense pathway that limits arterial plaque could complement statins and other therapies-but key questions wll be whether it works in humans, how durable the effect is, & whether it can be safely enhanced without unwanted immune or metabolic effects. – at Tartumaa, Eesti
Ajai Pathak retweeted
Imagine a system for people with diabetes that could continuously monitor glucose and keep its level steady and under control without drugs.
Oh, here it is, at least one that works well in mice
@ScienceMagazine science.org/doi/10.1126/scie…
Ajai Pathak retweeted
1/6 ❄️ Very happy to share our new study: “Cold activates a BH2 metabolic network promoting longevity and proteostasis.”
nature.com/articles/s41586-0…
#Aging #Longevity #Proteostasis #Metabolism #ALS #HuntingtonsDisease
Ajai Pathak retweeted
New online! Small variant calling in the era of long-read sequencing dlvr.it/TW0GMJ
Ajai Pathak retweeted
Happy to see my work with Regev Schweiger @Regevschweiger and Richard Durbin @richard_durbin now published in Genetics! Link to paper: academic.oup.com/genetics/ad… (open access). A thread on the main ideas....1/n
Ajai Pathak retweeted
मैं अरब हूँ। मैं मुसलमान हूँ। मैं अमीराती हूँ। 🇦🇪
और मैं भारत से प्रेम करता हूँ। 🇮🇳 मुझे उस भारत से प्रेम है जिसने मानवता को उपनिषद और भगवद्गीता, रामायण और महाभारत जैसे महान ग्रंथ दिए; उस भारत से, जिसने आत्मा, कर्तव्य, काल और अनंतता पर उस समय चिंतन किया था, जब हमारी आधुनिक दुनिया ने ऐसे प्रश्नों को “दर्शन” कहना भी नहीं सीखा था।
मुझे नालंदा और सिंधु घाटी का भारत प्रिय है; संस्कृत और तमिल का भारत, गणित और खगोलशास्त्र का भारत; वह भारत, जहाँ मंदिर मानो पत्थरों पर उकेरी गई कविताएँ हों, और जहाँ कहानियाँ दादा-दादी और नाना-नानी से बच्चों तक पीढ़ी-दर-पीढ़ी जीवित रहती हैं।
मुझे उस भारत से प्रेम है जहाँ हिमालय बादलों को छूता है, केरल मानसून को अपने भीतर समेट लेता है, राजस्थान रेगिस्तान को रंगों में बदल देता है, और जहाँ हज़ारों भाषाएँ आज भी अपने-अपने अंदाज़ में एक ही बात कहती हैं: यह मेरा घर है।
और मुझे भारत की सादगी में छिपी खुशियाँ भी उतनी ही प्रिय हैं: मसाला डोसा और सांभर, इडली, पनीर, दाल, बिरयानी और चाय।
क्योंकि भारत हज़ारों वर्षों का इतिहास केले के एक पत्ते पर परोसकर भी मुस्कुराते हुए पूछ सकता है: थोड़ा और लेंगे?
शायद इसीलिए, एक अमीराती होने के नाते, भारत मुझे कभी पूरी तरह पराया नहीं लगता।
सदियों से हमारे पूर्वज उसी हिंद महासागर के आर-पार एक-दूसरे की ओर देखते आए हैं। हमारे खाड़ी तटों से मोती भारत की ओर जाते थे, और हवाएँ वहाँ से मसाले, कपड़े, विचार और कहानियाँ लेकर हमारे तटों पर लौटती थीं।
अरब और भारत के बीच का समुद्र कभी दूरी नहीं था।
वह एक संवाद था।
बहुत कम राष्ट्रों को इतनी प्राचीन सभ्यता विरासत में मिली है, जो आज भी इतनी जीवंत हो।
साम्राज्य मिट गए।
सदियाँ गुज़र गईं।
सरहदें बदल गईं।
लेकिन भारत अपनी कहानियाँ सुनाता रहा।
उसकी प्रार्थनाओं ने भाषाएँ बदलीं।
उसके व्यंजन पीढ़ियों का सफ़र करते रहे।
उसकी पुस्तकों ने राजवंशों को जाते देखा और स्वयं जीवित रहीं।
उसके दर्शन ने सहस्राब्दियों को पार कर लिया।
और फिर भी, हज़ारों वर्षों के बाद, हर सुबह भारत जागता है और आज भी उतना ही विशिष्ट, उतना ही जीवंत, उतना ही भारत है।
शायद यही भारत का सबसे बड़ा चमत्कार है।
कुछ देशों के पास इतिहास होता है।
भारत की धड़कनों में सभ्यता बसती है।
एक अमीराती दिल से,
सम्मान, प्रशंसा और प्रेम के साथ। 🇦🇪❤️🇮🇳
Wondering what implications this might have for taller #humans ? Fascinating evidence that larger #dogs show accelerated #epigenetic aging—could body size influence the pace of molecular #aging more broadly?
#research #academia #genetics #epigenome – at Tartu, Eesti
Why do large dogs tend to live shorter lives than their smaller counterparts?
The answer may be written into their epigenome, according to a new study in Science. The findings reveal that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements.
Learn more: scim.ag/3VZtl3f
ALT A flowchart of the Dog Aging Project. It includes graphics of dogs, DNA, and data charts. Part A shows dog graphics with stars indicating enrollment locations. Part B features a chart of dog ages by size. Part C has box plots for types of dogs. Part D displays a graph of methylation changes over years.
Ajai Pathak retweeted
A paper in Nature Medicine presents a urine-based cell-free RNA test that detects bladder cancer with high sensitivity. go.nature.com/4y9PKIK
ALT This is figure 3, which shows urine-based detection of bladder cancer grade and invasiveness.
Ajai Pathak retweeted
Ancient Jumping Genes Turn Out to Be Hidden Architects of the Human Cortex bioengineer.org/ancient-jump…
Ajai Pathak retweeted
How much do PhD students earn?
The first comprehensive overview of PhD income shows vast imbalances across much of Europe
Read the full story: nature.com/articles/d41586-0…
