Cancer Biology PhD student at Stanford in the Khavari Lab
Joined July 2022
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Excited our work in the @apwiita lab made the cover of this month's @CellChemBiol - with fantastic artwork by Neil Wiita illustrating the interplay between proteasome inhibitor resistance and mitochondrial HSP70!
Ian Ferguson retweeted
Mitochondrial Raf1 regulates glutamine catabolism dlvr.it/TVQMQZ
Ian Ferguson retweeted
Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/ar…
Ian Ferguson retweeted
Rational discovery of VHL molecular glues. New Preprint from @Amgen Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/7 biorxiv.org/content/10.1101/…
Ian Ferguson retweeted
Today in @Nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide.
nature.com/articles/s41586-0…
Ian Ferguson retweeted
New @biorxivpreprint from @Amgen induced proximity group and @DanNomura lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 biorxiv.org/content/10.1101/…
Ian Ferguson retweeted
2- Linh and collaborators found that SMARCB1 regulates translation efficiency by combined nuclear and cytoplasmic roles
jbc.org/article/S0021-9258(2…
Thank you to our collaborators on both studies, and to reviewers and editors who made the process as smooth as possible!
Papers alert! The lab ended 2024 well with two published stories in Dec.
1- Anastasia @5_hmC and collaborators found that DMG have altered DNA replication and timing and are in a state of replication stress opening new potential therapeutic options.
genomebiology.biomedcentral.…
Ian Ferguson retweeted
Just in time for Christmas!
Optimal MAPK signaling for cell-fate programming...(1/2)
Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming biorxiv.org/cgi/content/shor… #biorxiv_sysbio
Ian Ferguson retweeted
New paper alert‼️ You’ve heard of multi-omics, but what about “functional multi-omics”? We combine CRISPRi screens, epigenetic analysis, cell surface #proteomics + phosphoproteomics to find determinants of CD38 regulation & dara efficacy in #myeloma #mmsm.
sciencedirect.com/science/ar…
Ian Ferguson retweeted
When you come across a paper that generates a large dataset (e.g., RNA-seq, CRISPR screen, etc.) that'd be incredibly useful for your own project.... but you look in the supplementary materials and realize the authors didn't include the raw data from the dataset:
Ian Ferguson retweeted
186 days later, and there are still more than 130 innocent people being held hostage by Hamas, deprived of medicine and contact with their loved ones. I just met with some of their families, and I was so deeply moved once again by their courage, strength and tenacity of spirit. They had a clear message: “There is no more time.”
I promised them we will advocate for them until each hostage is returned, and that we will not forget. We will not turn away. We will not move on. And we will not be silent.
Will you help them too? You can start by learning everything you can about the situation. Visit https://stories.bringthemhomenow.netto learn more. Then speak up—and spread the word.
We must #BringThemHomeNow.
Ian Ferguson retweeted
My piece today in @theatlantic is the product of five months of work, dozens of hours of interviews, and a lot of personal anguish. It tells the story of a campus consumed in unique fashion by bigotry, of reasonable students enabling rancor. Take a read!
theatlantic.com/ideas/archiv…
Ian Ferguson retweeted
I usually leave politics off this site. But the amount of antisemitism on display is pretty crazy. To all my Jewish friends and colleagues, I’m sorry and realizing I really didn’t understand/see it until now.
Ian Ferguson retweeted
Excited to share our work @NatureCancer, describing a new #chembio #massspec method to identify cancer-specific surface protein conformations ("structural surfaceomics"), and application to finding a new high-efficacy, low-toxicity CAR-T target in #AML link.springer.com/article/10…
Ian Ferguson retweeted
My op-ed on the ever-deepening rot of antisemitism at the core of American society.
“Something is rotten in the state of America. When the institutional leaders in our country cannot condemn the cold-blooded murder of Israeli civilians and children with moral clarity, one must ask: what kind of society are we becoming?”
“What does the silence and indifference and cowardice—from these so-called leaders—tell us about the depth of Antisemitism in America and the reckoning required?”
Read More:
nypost.com/2023/10/15/rep-ri…
Ian Ferguson retweeted
Our paper on chromosomal branching nucleation and spindle assembly is now out! Many new results in the final version: doi.org/10.1038/s41467-023-3…
Great work together with @SagarSetru, @shaevitz, @LabPetry, and Howard Stone.
Ian Ferguson retweeted
Congrats to Sami and Chin Fen on describing their new technology for rapid time-resolution cell surface proteomics! Check out the preprint👇 biorxiv.org/content/10.1101/…
Ian Ferguson retweeted
Today (and every day) I remember my parents, Nina and Emmanuel, who spent their childhood hunted like prey in Europe for being born Jewish
I also remember the many family members who did not survive. In a family tree I made in school, those murdered are marked with red lines
1/
Ian Ferguson retweeted
The helicase DDX21 is regulated by glucose binding in epidermal differentiation to live a second, non-nucleolar life; exciting story in Cell from W. Miao! authors.elsevier.com/sd/arti…
Ian Ferguson retweeted
I am thrilled to share our micro-review in @cell_stress along with @idferguson @apwiita about surfaceome in #myeloma to come up to new immuno-therapeutic targets and markers of resistance !
Bonell Patiño-Escobar, Ian D. Ferguson and Arun P. Wiita @apwiita discuss their recent @NatureComms paper in a minireview: "Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance" cell-stress.com/researcharti…
