Professor at King's College London
London, UK
Joined November 2012
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Our paper on longitudinal multi-omics in an aging population is out at @ScienceMagazine
Led by @Julia_Moustafa , we profiled gene expression and metabolomics at 3 timepoints in 335 individuals over 6-8 years to investigate molecular aging trajectories
science.org/doi/10.1126/scie…
Very excited to share that our manuscript on cis-eQTL analysis of adipose tissue gene expression in 2,344 samples is now out in Nature Genetics
rdcu.be/d5ov4
See thread from lead author @SarahBrotman below
I’m excited to share that this manuscript is now published in Nature Genetics! 🧪🧬 🖥️
nature.com/articles/s41588-0…
The AdipoExpress data can be accessed here: zenodo.org/records/13845120
An interactive browser of the colocalization results can be accessed here: adipose.colocus.app
Kerrin Small retweeted
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.1101/…
Kerrin Small retweeted
Excited to share our new preprint in which we address:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/15]
medrxiv.org/content/10.1101/…
Kerrin Small retweeted
II'm excited to finally share our study on the mutational landscape and selection dynamics in sperm, now live on medRxiv: medrxiv.org/content/10.1101/…. We explored how positive selection impacts mutation rates, especially with age. Here’s a quick thread on our findings! 🧵👇
Kerrin Small retweeted
Several group leader positions available in Dept. of Medical and Molecular Genetics at King's College London (from lecturer to professor) - an exciting opportunity to join a thriving human genetics community and build something brilliant! tinyurl.com/4c8z8hnw
Kerrin Small retweeted
I am excited to share our preprint describing a collaborative effort to identify conditionally distinct signals in the largest adipose eQTL dataset to date (AdipoExpress)! @kerrin_small, @klmohlke, Laura Scott, @Julia_Moustafa, @mikelove, and others. 1/8
biorxiv.org/content/10.1101/…
Our paper in collaboration with @MinaRyten and led by Karishma D’Sa
nature.com/articles/s41598-0…
Kerrin Small retweeted
Excited to share a local maximum of my grad school roller coaster ride: our paper “The origins and functional effects of postzygotic mutations throughout the human life span” is now published in @sciencemagazine: science.org/doi/10.1126/scie…. 1/4
Our paper led by @anto_zito investigating variation in escape from X-inactivation across tissues, individuals and twin pairs is now published in @PlosGenetics dx.plos.org/10.1371/journal.…
Many thanks to @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @TwinsUKres
Our paper led by @A_L_Roberts on skewed X chromosome inactivation and its relationship with molecular and cellular measures of aging, cardiovascular disease risk, and cancer diagnoses is online at @elife
doi.org/10.7554/eLife.78263
Kerrin Small retweeted
We're recruiting a Chair in Population Health Sciences & HoD of Population Health Sciences.
Population Health is a major new strategic priority for King’s & we're looking for an innovative & committed leader.
Deadline: 14 July 🗓️
Apply 👇
jobs.ac.uk/job/CQO420/chair-…
Our paper investigating ACE2 gene expression in adipose tissue across three cohorts is now online at @IntJObesity
Work led by @Julia_Moustafa in collaboration with Anne Jackson, Li Guan, @SarahBrotman @klmohlke Laura Scott and others
nature.com/articles/s41366-0…
Kerrin Small retweeted
We conducted a transcriptomic survey to study properties of escape from X-inactivation across tissues and cells in female twins. @A_L_Roberts @_alesssia @Julia_Moustafa @MarioFalchi @kerrin_small @TwinsUKres
biorxiv.org/content/10.1101/…
Kerrin Small retweeted
**New!** London Genetics Network
- online launch meeting 4th Dec 2020
- early career poster prize
- great speaker line up
- all London human geneticists welcome
- forum to discuss network's remit
Register here: eventbrite.co.uk/e/launch-me… PLEASE RT
Kerrin Small retweeted
Recruiting for a 4-year BBSRC-funded PhD studentship in computational genomics of human skin ageing at @KingsCollegeLon in collaboration with Unilever; co-supervised by @kerrin_small and David Gunn.
UK/EU fees covered. Deadline 15 Oct 2020.
findaphd.com/phds/project/re…
Our preprint “ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition”, with @Julia_Moustafa Anne Jackson, Li Guan @SarahBrotman @klmohlke Laura Scott @TwinsUKres 1/4
ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition medrxiv.org/cgi/content/shor… #medRxiv
Adipose ACE2 expression was associated with the estimated cell type content of biopsies; positively correlated with proportion of microvascular endothelial cells (known to express ACE2 in other cardiovascular tissues) and negatively correlated with proportion of macrophages 3/4