Pedro Leão retweeted
Trichlorination by a single cyanobacterial halogenase in the biosynthesis of lebomboamide A dlvr.it/TTyk6V
Pedro Leão retweeted
Our latest paper is now out in @angew_chem: we uncover a new enzymatic transformation where a SAM-dependent methyltransferase catalyzes a Wagner–Meerwein-like rearrangement to generate a vinyl group during fischerazole biosynthesis 🧬
@CiimarUp
onlinelibrary.wiley.com/doi/…
Pedro Leão retweeted
🚀 New paper & tool out: FAALPred - our AI tool to predict fatty acid chain-length specificity of FAAL enzymes from protein sequence.
🔗faalpred.ciimar.up.pt/
@CiimarUp @ICBAS_UPorto @leao_lab @mattoslmp @pnleao @BlueBio4Future
📄 onlinelibrary.wiley.com/doi/…
Pedro Leão retweeted
Check out our group’s just-published paper in @NatureComms: a macrocyclase with a built-in kinase domain that can phosphorylate peptides during RiPP biosynthesis and be swapped into other pathways 🧬 @BlueBio4Future @CiimarUp
nature.com/articles/s41467-0…
Pedro Leão retweeted
Our latest work is out in Nature Chemical Biology @nchembio and featured by @PennEngineers: We discovered new fungal RiPPs, aspergimycins, from Aspergillus flavus, with promising anti-leukemia activity via lipid modification. blog.seas.upenn.edu/penn-eng…
Pedro Leão retweeted
🌟 Exciting News! Our review on Fatty acyl-AMP ligases (FAALs) in bacterial natural product biosynthesis has just been published in Natural Product Reports, Royal Society of Chemistry! 🎉
Special thanks to @pnleao @BlueBio4Future @CiimarUp @ICBAS_UPorto
pubs.rsc.org/en/content/arti…
Pedro Leão retweeted
The @cmiaviladoconde is hosting the online talk “Natural Products: Discovery, Isolation, and Biotechnological Applications of Nature's Most Valuable Secrets” by @CiimarUp researcher Sara Freitas.
🗓️ November 22
🕐 14h
👉 forms.gle/UP3aAJZQvpNdEVa2A
@BlueBio4Future
#CIIMARcmias
Pedro Leão retweeted
Homonuclear Super-Resolution #NMRspectroscopy (Roland Riek and co-workers) @ETH_DCHAB #nmrchat #openaccess onlinelibrary.wiley.com/doi/…
Pedro Leão retweeted
Lipidation Engineering in Daptomycin Biosynthesis | Journal of the American Chemical Society pubs.acs.org/doi/full/10.102…
Pedro Leão retweeted
Our paper on a new #AMG #tetrapyrrole is finally out. Spearheaded by @SheilaRoitman @Helen_Phage nature.com/articles/s41467-0…
Pedro Leão retweeted
We developed a versatile genome mining strategy to explore the biosynthetic space of the atropopeptides - a fascinating family of peptides with complex 3D shapes!
Now out in @ChemicalScience
#peptides #biosynthesis #genomemining
pubs.rsc.org/en/content/arti…
Pedro Leão retweeted
📢The future Pereira lab is hiring! We will start at @_VIB_AI in February 2025 and are looking for a postdoc to join and kick-start our team 🤓 If you want to leverage AI and large networks to explore and understand the protein universe 🌌, check below! jobs.vib.be/j/93314/postdoc-…
Pedro Leão retweeted
Excited to share an awesome collab between the @NarayanLab ang @gpggrp! Check out our preprint on CATNIP, using ML to help chemists identify a compatible biocatalyst for small molecule synthesis! Huge thanks to @daniil_boiko for making it all possible!🎉chemrxiv.org/engage/chemrxiv…
Pedro Leão retweeted
Save the date! 📢
We are excited to announce M2C2-2025: Marine Microbial Chemical Communication, a conference exploring cutting-edge research on chemically mediated microbial interactions in the marine environment. The conference will take place from March 17-20, 2025, at NIOZ >>
Pedro Leão retweeted
Very excited to share that one of the major projects from my postdoc in the wonderful @piel_lab is out now @Chem_CP. An amazing collaboration with the @ChekanLab and @sanathrajkk0 where we characterized RiPPs with polycyclic isoprene moieties🎉 authors.elsevier.com/c/1jjdi…
Pedro Leão retweeted
Join us for an online lecture by Paulo Oliveira from @BlueBio4Future team "Synthetic Biology & Marine Biotechnology for a Blue Bioeconomy" as part of the "What is the Future of Marine Biotechnology?" exhibition at @cmiaviladoconde
🗓️Sept 16th
🕝 14h30
@REA_research @CiimarUp
🌏 Palestra Online «Biologia Sintética e Biotecnologia Marinha para o desenvolvimento de uma Bioeconomia Azul»
📆 16 de setembro
🕐 14h30
👉 A inscrição é gratuita e obrigatória e deve ser feita em: forms.gle/ZxWTp2nH91Wp7Kvf7
👉 Público-alvo: Público em geral
@CiimarUp
Pedro Leão retweeted
The value of ‘wasting time’ on deep thinking is often overlooked in a scientific ecosystem increasingly tainted by Wall Street’s productivity mindset.
nature.com/articles/d41586-0…
Pedro Leão retweeted
Thrilled to update that our phenazine halogenase manuscript is accepted and online at Org Lett @JOC_OL! Huge congrats to @JacksonBaumga10 for spearheading this fun and colorful story - check it out here:
pubs.acs.org/doi/10.1021/acs…
Excited to share our newest pre-print on a novel vanadium enzyme that catalyzes regioselective halogenation on a phenazine meroterpenoid! Check it out if you like biosynthesis, enzyme discovery, chemoenzymatic synthesis, or fun colors!
@JacksonBaumga10
chemrxiv.org/engage/chemrxiv…
Pedro Leão retweeted
A big one out from our lab - combining synthesis and enzymology to look in detail into BVMO product selectivity! Very proud of team @techbiodd with @ManuEinsiedler in the lead. Work done @Helmholtz_HIPS @Helmholtz_HZI @tudresden_de @TUD_Science @J_A_C_S
pubs.acs.org/doi/full/10.102…
Pedro Leão retweeted
We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio
nature.com/articles/s41589-0…
