Simanshu Dhirendra (@simanshu) header
Simanshu Dhirendra (@simanshu) profile picture

Simanshu Dhirendra

@simanshu

Group lead (Structural Biology) at NCI RAS Initiative @FredNatLab; RAS/RAF/PI3K structural biology and drug discovery

 Frederick, MD
cancer.gov/research/key-initiatives/ras/research-teams/structural-biology
Joined April 2009
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  • Followers157
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Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)Photo by Simanshu Dhirendra (@simanshu)
Simanshu Dhirendra retweeted
Pau Castel (@castel_pau) profile picture
Pau Castel@castel_pau11 Sep 2025
Excited to share our latest work onll LZTR1 just published @ScienceMagazine!! A wonderful multidisciplinary collaboration between @simanshu's lab and our lab that provides structural understanding on RAS substrate and nucleotide specificity, and effect of mutations in LZTR1.
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Molecular Cell (@MolecularCell) profile picture
Molecular Cell@MolecularCell17 Jul 2024
Online Now: Functional and structural insights into RAS effector proteins dlvr.it/T9kDnf
Image from Molecular Cell (@MolecularCell)
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Simanshu Dhirendra retweeted
Pau Castel (@castel_pau) profile picture
Pau Castel@castel_pau17 Jul 2024
Check out our latest review regarding the biology of RAS GTPase effectors! It was fun to write this with @AmMozzarelli and @simanshu for @MolecularCell. Bottom line: lots of knowledge on these proteins, but many questions that remain to be answered. cell.com/molecular-cell/full…
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Simanshu Dhirendra retweeted
AACR (@AACR) profile picture
AACR
@AACR8 Apr 2024
The three-part New Drugs on the Horizon Series at the AACR Annual Meeting 2024 wrapped up this morning. A total of 12 first-time disclosures were presented. bit.ly/3J8AmVM #AACR24
Image from AACR (@AACR)
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Simanshu Dhirendra retweeted
Kotaro Nakanishi (@ktr_nakanishi) profile picture
Kotaro Nakanishi@ktr_nakanishi5 Oct 2023
Happy to host @simanshu, an expert on RAS proteins @FredNatLab. His seminar is at 006 Psychology from 4:10 pm on 10/5 (Thu). #cancer @OSU_CBC @OSUCCC_James chemistry.osu.edu/events/dr.…

Dr. Dhirendra Simanshu - Biochemistry Seminar

Dr. Dhirendra Simanshu, Frederick National Laboratory for Cancer Research, Frederick Maryland Presentation title: "Role of RAS and SHOC2 in RAF activation" Host: Dr. Kotaro Nakanishi

chemistry.osu.edu
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Simanshu Dhirendra retweeted
Cancer Research (@CR_AACR) profile picture
Cancer Research@CR_AACR4 Oct 2023
From the newest issue— Allosteric Regulation of Switch-II Domain Controls #KRAS Oncogenicity, by @simanshu, @FredNatLab, @KevinHaigisLab et al. bit.ly/3tgS8kZ @DanaFarberNews
Image from Cancer Research (@CR_AACR)
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Johannes Morstein (@mo_hannes) profile picture
Johannes Morstein@mo_hannes14 Aug 2023
Excited to share our latest work on a bifunctional approach to target protein-membrane interactions (PMIs) @kevansf @UCSFCancer & great collaboration with @NIH @FredNatLab @LosAlamosNatLab @UTHealthHouston - @ACSPublications #KRas #lipidtime #membranes pubs.acs.org/doi/10.1021/acs…
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SBGrid's eLife paper received a new citation in May from #SBGrid member @simanshu @FredNatLab for Cancer Research contributing to @jbiolchem: The Ribosomal S6 Kinase 2 (RSK2)-SPRED2 complex regulates phosphorylation of RSK substrates and MAPK signaling. buff.ly/3qyWgLG
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Simanshu Dhirendra retweeted
Communications Biology (@CommsBio) profile picture
Communications Biology@CommsBio2 Jun 2023
Structural analysis reveals an intermediate (excited) state of GMPPNP-bound KRASG13D which includes the formation of a new pocket in the allosteric lobe that could be exploited for developing new therapeutics against KRASG13D-driven cancers. nature.com/articles/s42003-0…

Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

Communications Biology - Structural analysis reveals an intermediate (excited) state of GMPPNP-bound KRASG13D which includes the formation of a new pocket in the allosteric lobe that could be...

nature.com
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Simanshu Dhirendra retweeted
Daniel Gerlach (@gerlach_d) profile picture
Daniel Gerlach@gerlach_d2 Jun 2023
Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D | Communications Biology nature.com/articles/s42003-0…

Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

Communications Biology - Structural analysis reveals an intermediate (excited) state of GMPPNP-bound KRASG13D which includes the formation of a new pocket in the allosteric lobe that could be...

nature.com
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Proud of this review we just published! Oncogenic KRAS really hijacks many cellular processes…including the miRNA regulatory pathway! – at Houston, TX
Cancer Research (@CR_AACR) profile pictureCancer Research@CR_AACR31 May 2023
#ICYMI— @GinaBortoletto and @ronparchem review the ability of #KRAS to hijack the #miRNA regulatory pathway and discuss potential therapeutic strategies to exploit this KRAS function. bit.ly/43xlb0z @bcmhouston
Image from Cancer Research (@CR_AACR)
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Pau Castel (@castel_pau) profile picture
Pau Castel@castel_pau11 May 2023
In collaboration with @simanshu's group, they also provided structural insights into residues involved in such interaction.
Image from Pau Castel (@castel_pau)
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Simanshu Dhirendra retweeted
Pau Castel (@castel_pau) profile picture
Pau Castel@castel_pau11 May 2023
Congratulations to @JLo_science on her first first-author paper from her graduate work at the McCormick Lab!! 🥳🥳 Jocy identified the RSK2 kinase as a novel interactor of Spred2 and identified the potential role of such interaction. sciencedirect.com/science/ar…
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Simanshu Dhirendra retweeted
Molecular Cell (@MolecularCell) profile picture
Molecular Cell@MolecularCell21 Apr 2023
Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions dlvr.it/SmsTnL

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not...

An open question in RAS biology is the existence of RAS dimers and their role in RAF dimerization and activation. The authors review the evidence for RAS dimerization and describe recent discussions...

cell.com
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Simanshu Dhirendra retweeted
AACR (@AACR) profile picture
AACR
@AACR15 Apr 2023
#AACR23 Program Chair Robert Vonderheide joins the participants in the Saturday Plenary Session on Beating KRAS: A 30-Year Overnight Sensation— Pasi A. Jänne, session chair Dafna Bar-Sagi, Beatriz M. Carreno, and Frank McCormick.
Image from AACR (@AACR)
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Trapping KRAS GTP in an inactive state @simanshu & colleagues @FredNatLab and @UCSFCancer @kevansf and team get shout-outs from Dr. McCormick for their outstanding work in the Ras field over the past decade. Next generation of KRAS inhibitors is moving along nicely #AACR23
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Simanshu Dhirendra retweeted
Lander Lab (@LanderLab) profile picture
Lander Lab@LanderLab2 Apr 2023
All smiles at Kelli Hvorecny’s ISOLDE tutorial at the ⁦@CSHL⁩ #cryoem course!
Image from Lander Lab (@LanderLab)
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Simanshu Dhirendra retweeted
Jennifer Cash (@Jen_Cash_11) profile picture
Jennifer Cash@Jen_Cash_1130 Mar 2023
A surprise for students in the #cryoEM @cshlcourses today - group members were shuffled to form new working groups for the rest of the course. The reactions were priceless! Competitions underway…
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
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Simanshu Dhirendra retweeted
Charlotte Crowe (@CharlCrowe) profile picture
Charlotte Crowe@CharlCrowe30 Mar 2023
Group 2's @cshlcourses #cryoEM apoferritin grid freezing is underway! Let the competition begin! ❄️ @kayla_m_perry_ @FirasFadel_BZ
Image from Charlotte Crowe (@CharlCrowe)
Image from Charlotte Crowe (@CharlCrowe)
Image from Charlotte Crowe (@CharlCrowe)
Jennifer Cash (@Jen_Cash_11) profile pictureJennifer Cash@Jen_Cash_1130 Mar 2023
A surprise for students in the #cryoEM @cshlcourses today - group members were shuffled to form new working groups for the rest of the course. The reactions were priceless! Competitions underway…
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
Image from Jennifer Cash (@Jen_Cash_11)
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Simanshu Dhirendra retweeted
Jennifer Cash (@Jen_Cash_11) profile picture
Jennifer Cash@Jen_Cash_1131 Mar 2023
Peter Rosenthal talks with us about #cryoEM validation in our @cshlcourses today.
Image from Jennifer Cash (@Jen_Cash_11)
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