Immunologist at The University of Pennsylvania / Senior Research Investigator / Wherry lab / Tango dancer / Cat mom
Joined January 2017
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So excited to share our work out in @NatImmunol !!! We analyzed antigen-specific CD8 T cells differentiating down effector/memory vs exhaustion (Exh) lineages using scRNAseq/scATACseq. Major findings 👇
@EJohnWherry @PennMedicine
nature.com/articles/s41590-0…
Dr. Josephine Giles retweeted
What a PERFFect day to share our new preprint!
With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.1101/… 1/n
Dr. Josephine Giles retweeted
I'm excited to share our new work on antibody and B cell responses to BA.5 and XBB.1.5! We look at how immune memory from prior exposures to SARS-CoV-2 shapes the relative contributions of cross-reactive vs. variant-specific responses. See thread below!
medrxiv.org/content/10.1101/…
Check out our new manuscript on
@medrxivpreprint. We show that ‘immune imprinting’ with ancestral SARS-CoV-2 mRNA vaccines is beneficial for priming neutralizing antibody responses against emerging SARS-CoV-2 variants. 1/n medrxiv.org/content/10.1101/…
Yay! So excited to see this story OUT. Congrats @simpak
Are all skin TRM cells created equal? Beyond excited to share our new paper in @ScienceMagazine, where we show diverse CD8+ TRM use distinct molecular pathways to develop and persist in skin, which we can target to fine-tune the skin-immune landscape🧵👇🏻 science.org/doi/10.1126/scie…
Great work @CalebLareau ! Congratulations:)
Out today in @Nature, we describe HHV-6 reactivation in T cells, including therapeutic CAR T cells. I’m so grateful to have worked with an all-star team during my time in the @Satpathology lab that led to these findings. nature.com/articles/s41586-0… 1/n
Dr. Josephine Giles retweeted
Loved seeing everyone at the @ShlomchikLab 30yr symposium
While not in this photo, one thing the symposium highlighted was that @KMNickerson is the heart of the lab!
@balaguri we missed you but glad we could see you via zoom
So excited for the new building!
Amazing things happening at Penn! Toured our new building this week. Home for @UPenn_I3H, @_ImmuneHealth_, The Colton Center for Autoimmunity. Open mid-2025. There's an #Immunorevolution happening @ Penn. Exciting times Autoimmunity, Immunotherapy, CAR T, RNA science, Nobel Prize
Dr. Josephine Giles retweeted
We are recruiting faculty in The Colton Center for Autoimmunity at UPenn! Come join an amazing immunology community with major opportunities in Autoimmunity and #ImmuneHealth including a new building in 2025.
apply.interfolio.com/131742
apply.interfolio.com/131761
Yay! Looking forward to seeing everyone 😀
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Our review is out in @ImmunityCP reviewing CD8 T cells in the Cancer-Immunity Cycle! A wonderful anniversary issue with reviews covering many aspects of the CIC originally described by @DanChenMDPhD and Ira Mellman. Wonderful working with @AnnaGlobig @Tcellogic @EJohnWherry!
CD8+ T cells in the cancer-immunity cycle: CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, Giles, & Globig review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates T cell metabolism and the impact of the tumor microenvironment. authors.elsevier.com/a/1huvh…
Dr. Josephine Giles retweeted
Congratulations to one of our new medicine laureates: Katalin Karikó (@kkariko)! 🎉
An interview with her will be coming soon.
ALT Katalin Karikó on the phone with her sister. She is smiling.
Yay!!! Congratulations @markmpainter Excited to see this out!
I'm excited to see our work on immune responses during SARS-CoV-2 breakthrough infection out in @NatImmunol! The results highlight the broad benefits of vaccination and especially the role of memory T cells in the critical early stages of the infection.
nature.com/articles/s41590-0…
Wahoo!!!!! Congratulations @AnnaGlobig
Fascinating discovery by @Annaglobig! Exhausted CD8 T cells talk to sympathetic nerves in tissues & tumors. Tex cells express ADRB1 and localize near sympathetic nerves, listening to stress hormone noradrenaline. This promotes their dysfunction. nature.com/articles/s41586-0…
Beautiful and thoughtful new paper by @jenewu1 . Really proud of this one.
In vitro models of CD8 T cell exhaustion make high-throughput interrogation easy, but can they be used to discover real Tex biology with therapeutic relevance?
Read to find out! In our new work from the @EJohnWherry lab, out now at @SciImmunology, we...
bit.ly/45yOFMB
Yay! Congratulations @SusanMcClory :)
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Excited to present at the MULTIOMICS IN PRECISION MEDICINE 2023! Hope to see you all there :)
web.cvent.com/event/7d60d045…
Dr. Josephine Giles retweeted
Super excited to share our work on the differential roles of distinct versions of SWI/SNF chromatin remodelling complexes in CD8 T cell exhaustion! A huge team effort from labs of @EJohnWherry , Martha Jordan and @junwei_s. doi.org/10.1016/j.immuni.202…
Dr. Josephine Giles retweeted
The documentation required to get reimbursed for a scientific conference:
#AcademicTwitter @AcademicChatter
Dr. Josephine Giles retweeted
In case you missed it: Women are less likely to be credited for their scientific contributions than men. It’s true across multiple fields & at all stages, with important repercussions for career progress. #WomenInSTEM #WomenInMedicine #MedTwitter
nature.com/articles/s41586-0…
Congratulations @TheVinodLab and all the authors!!!! Really important and exciting work. Wonderful to see this story in print!
1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3.
"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)
If each patient = own NAs, how do you vaccinate?
Maybe mRNA? But how?
@Nature nature.com/articles/s41586-0…
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