Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS | opinions are my own and do not reflect those of my employer
Madison, WI
Joined November 2018
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Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
Judith Simcox PhD retweeted
Honored to receive a 2026 Glenn Foundation for Medical Research Grant for Junior Faculty!! Grateful for the generous support and mentorship from @longlabstanford @LammingLab @JudithSimcox, and the support from our department @UWBiochem
afar.org/grantee-profiles/we…
Judith Simcox PhD retweeted
🚀 First paper from the Cluntun Lab!
Our invited Perspective is now out in @BiochemistryACS.
A framework for understanding lactate biology through subcellular routing and chemical form.
pubs.acs.org/doi/10.1021/acs…
@ACSPublications @RutgersHealth
Congratulations @NichoOffei!
Judith Simcox PhD retweeted
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s41586-0… @UofUBiochem 1/10
Judith Simcox PhD retweeted
Cells make toxic metabolites every minute they’re alive. How do they survive them?
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/scia…
Judith Simcox PhD retweeted
Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis
go.nature.com/4BuXDLz
Judith Simcox PhD retweeted
🚀 Applications are NOW OPEN for the 2026 Rising Star in Computational Mass Spectrometry Research Award!
Supported by @ChanZuckerberg, @OpenMSTeam, and the @UofT, this award celebrates and empowers rising talent in our field.
More information ➡️ lnkd.in/gzDuppnb
Judith Simcox PhD retweeted
Adipocyte Lipolysis is a Determinant of Skeletal Muscle Size During Fasting and Feeding
journals.physiology.org/doi/…
Judith Simcox PhD retweeted
Our new work by @YuyangLiu1996! Short-lived proteins are key regulators of metabolic homeostasis. By investigating their degradation, we identified TXNDC15 as a regulator of ER protein degradation and lipid homeostasis via a catalysis-independent mech. cell.com/cell-chemical-biolo…
Judith Simcox PhD retweeted
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/S0092…
Judith Simcox PhD retweeted
Huge thanks to my co-authors and to the @RutterLab, @gsducker, @JLS_Lab and @dr_ohsopretty labs for making this project possible. 🙏🏾 Read the preprint here: biorxiv.org/content/10.64898… 💪🏾🔥🎉 @UofUBiochem @hhmi_science
Judith Simcox PhD retweeted
We are excited to share this new preprint from our amazing postdoc, @luisci22! Luis discovered that liver cancer cells with overactive beta-catenin switch their mitochondrial fuel usage from glucose to fatty acid oxidation—an unexpected rewiring that challenges conventional Warburg metabolism.
Excited to share my new preprint from the @RutterLab! What sets a cell’s metabolic state? Using MPC1 as a readout in a CRISPR screen, we found that β-catenin regulates metabolic state in liver cancer cells, driving a switch from carbohydrate to fat oxidation. 🧵
Judith Simcox PhD retweeted
We are recruiting a postdoc to build ML/AI tools to integrate spatial multiomics to study cancer and neurodegenerative diseases. nature.com/naturecareers/job…
Judith Simcox PhD retweeted
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.
Please spread the word on hiring in our department. We are searching broadly but particularly interested in Systems and Synthetic Biology. I am chairing this faculty search, please feel free to reach out if you have any questions.
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.
Judith Simcox PhD retweeted
And…
I am SO excited to share our first research preprint! In this paper we determined several cryoEM structures to visualize the entire cell-to-cell bridging complex formed by TAM receptor and ligand, bringing into 3D a common graphical depiction.
biorxiv.org/content/10.64898…
Judith Simcox PhD retweeted
A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity: nature.com/articles/s41594-0…
Judith Simcox PhD retweeted
Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity:
biorxiv.org/content/10.64898…
Judith Simcox PhD retweeted
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @AJsmith231, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
biorxiv.org/content/10.64898…
# Mitochondria
#HHMINews
Judith Simcox PhD retweeted
Our 🆕 paper alert ‼️ Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder our review published in @NatRevNeph @AranyLab @IntMedAbel @pei_liming @JosephABaur nature.com/articles/s41581-0…
