Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS | opinions are my own and do not reflect those of my employer
Madison, WI
Joined November 2018
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Judith Simcox PhD retweeted
Honored to receive a 2026 Glenn Foundation for Medical Research Grant for Junior Faculty!! Grateful for the generous support and mentorship from @longlabstanford @LammingLab @JudithSimcox, and the support from our department @UWBiochem
afar.org/grantee-profiles/we…
Judith Simcox PhD retweeted
🚀 First paper from the Cluntun Lab!
Our invited Perspective is now out in @BiochemistryACS.
A framework for understanding lactate biology through subcellular routing and chemical form.
pubs.acs.org/doi/10.1021/acs…
@ACSPublications @RutgersHealth
Congratulations @NichoOffei!
Judith Simcox PhD retweeted
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s41586-0… @UofUBiochem 1/10
Judith Simcox PhD retweeted
Cells make toxic metabolites every minute they’re alive. How do they survive them?
In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
science.org/doi/10.1126/scia…
Judith Simcox PhD retweeted
Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis
go.nature.com/4BuXDLz
Judith Simcox PhD retweeted
🚀 Applications are NOW OPEN for the 2026 Rising Star in Computational Mass Spectrometry Research Award!
Supported by @ChanZuckerberg, @OpenMSTeam, and the @UofT, this award celebrates and empowers rising talent in our field.
More information ➡️ lnkd.in/gzDuppnb
Judith Simcox PhD retweeted
Adipocyte Lipolysis is a Determinant of Skeletal Muscle Size During Fasting and Feeding
journals.physiology.org/doi/…
Judith Simcox PhD retweeted
Our new work by @YuyangLiu1996! Short-lived proteins are key regulators of metabolic homeostasis. By investigating their degradation, we identified TXNDC15 as a regulator of ER protein degradation and lipid homeostasis via a catalysis-independent mech. cell.com/cell-chemical-biolo…
Judith Simcox PhD retweeted
Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
cell.com/cell/fulltext/S0092…
Judith Simcox PhD retweeted
Huge thanks to my co-authors and to the @RutterLab, @gsducker, @JLS_Lab and @dr_ohsopretty labs for making this project possible. 🙏🏾 Read the preprint here: biorxiv.org/content/10.64898… 💪🏾🔥🎉 @UofUBiochem @hhmi_science
Judith Simcox PhD retweeted
We are excited to share this new preprint from our amazing postdoc, @luisci22! Luis discovered that liver cancer cells with overactive beta-catenin switch their mitochondrial fuel usage from glucose to fatty acid oxidation—an unexpected rewiring that challenges conventional Warburg metabolism.
Excited to share my new preprint from the @RutterLab! What sets a cell’s metabolic state? Using MPC1 as a readout in a CRISPR screen, we found that β-catenin regulates metabolic state in liver cancer cells, driving a switch from carbohydrate to fat oxidation. 🧵
Judith Simcox PhD retweeted
We are recruiting a postdoc to build ML/AI tools to integrate spatial multiomics to study cancer and neurodegenerative diseases. nature.com/naturecareers/job…
Judith Simcox PhD retweeted
Deadline Oct. 15: We are hiring for a professor at any level to join our creative and dynamic community. Candidates in all areas of #biochemistry will be considered, and we are particularly interested in candidates in systems and synthetic biology. jobs.wisc.edu/jobs/assistant…
ALT Poster for job ad. Read further details at jobs.wisc.edu. Job number JR10012489.
Judith Simcox PhD retweeted
And…
I am SO excited to share our first research preprint! In this paper we determined several cryoEM structures to visualize the entire cell-to-cell bridging complex formed by TAM receptor and ligand, bringing into 3D a common graphical depiction.
biorxiv.org/content/10.64898…
Judith Simcox PhD retweeted
A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity: nature.com/articles/s41594-0…
Judith Simcox PhD retweeted
Lac-Phe is an exercise💪 and metformin💊 inducible blood-borne metabolite that suppresses appetite. How does Lac-Phe get into circulation? New from @Shuke_Xiao: a transporter deorphanization story that links local cellular metabolism to systemic activity:
biorxiv.org/content/10.64898…
Judith Simcox PhD retweeted
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @AJsmith231, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
biorxiv.org/content/10.64898…
# Mitochondria
#HHMINews
Judith Simcox PhD retweeted
Our 🆕 paper alert ‼️ Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder our review published in @NatRevNeph @AranyLab @IntMedAbel @pei_liming @JosephABaur nature.com/articles/s41581-0…
Judith Simcox PhD retweeted
Awesome paper on bitter taste in the #mosquito
Congrats @BenMatthewsUBC @trevor_sorrells and co-authors!
biorxiv.org/content/10.64898…
