Paulina García (@Paulinag212) header
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BSc Neuroscience @UNAM_MX 🧠✨ Sleep, circadian rhythms, blood-brain barrier, cellular senescence, mitophagy, neurodegeneration, ageing, cognition, data analysis

Joined April 2024
I am deeply honored to have received the UNAM “Dr. Gustavo Baz Prada” 2024 Award for my social service project, which focused on evaluating how chronic sleep loss impacts memory and blood-brain barrier function. Super grateful for the opportunity to do science! 🔬🧠😴
🥇Premio al Servicio Social Gustavo Baz Prada 2024🥇 ¡Felicidades Paulina García López! #orgulloneurociencias🧠💙 #PremioServicioSocial #NeurocienciasCU
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How much of adipocyte rhythms are driven by the cell’s own clock vs. signals from the body? A new #JBR study finds 21% of transcripts are rhythmic in cultured adipocytes, revealing cell-autonomous regulation of metabolism, transport, and transcription. journals.sagepub.com/doi/10.…
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Researchers find in mice that cells in the brain’s network of blood vessels also support neural circuits in the cerebellum that govern motor coordination—expanding current paradigms of the role of the brain’s vasculature in neurodevelopment. @SciSignal scim.ag/4Bi4o3k
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🎉 The wait is over! The FIRST in-person @Ibero_ICSA meeting is happening in Mexico City! 🗓️ March 16–19, 2027 Join us as we bring together the Ibero-American and international cellular senescence community! 🔗 smb.org.mx/ibero-icsa-2027/
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Researchers in @ScienceAdvances have developed a cross-national “speech clock” that can track biological aging and markers of dementia across a large and diverse sample of Latin American populations. scim.ag/47rTx99
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Excited to share my lab’s latest preprint led by postdoc @YukiHaba_ and grad student Ryan Schwark. We surprisingly find that spontaneous behavior in isolation predicts a naked mole-rat’s identity, its colony membership, and even rank within its colony. biorxiv.org/content/10.64898…
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The way we age differs from person to person, but what shapes these trajectories? A new #Science study found that 26% of genes and 39% of metabolites showed circadian-associated variation, highlighting how our clocks may influence the molecular changes we see with aging.
Aging does not appear to follow the same molecular script for everyone, according to an 8-year study of more than 300 women. The findings in Science reveal that individual molecular trajectories of aging can diverge substantially from population-wide patterns and are shaped not only by genetics but also by factors such as circadian rhythm, seasonality, and environmental exposures. Learn more: scim.ag/4ikMUfG
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📢The abstract submission deadline has been extended to September 19!!! Don't miss this oportunity! Submit your abstract here 👇🏼 forms.cloud.microsoft/Pages/… @WAutophagy #Autophagy #womeninscience #WomenInAutophagy #cellbiology #science #researchcomunity #scientificsymposium – at Álvaro Obregón, Distrito Federal
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🔔⏳Submit your abstract by September 6th to be part of the event!!! 📢. Link here: forms.cloud.microsoft/Pages/… #autophagy #STEM #ScienceAlert #science @WAutophagy – at Distrito Federal, México
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Online now!✨Martinez, Morandini et al identify a role for cGAS in chromatin organization: cGAS knockout mice show compromised heterochromatin organization, LINE1 depression, inflammation, and shortened lifespan nature.com/articles/s43587-0…
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Online now!✨Wang et al report a role for CDK4/6 in regulating not only cell cycle progression but also the SASP, via retinoic acid signaling and NFkB. Targeting this pathway reduces inflammation and improves function in aged mice @Marc_dema nature.com/articles/s43587-0…
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Research Spotlight Can glial inflammation drive sleep disruption in Alzheimer's disease? Macheda et al. show that blocking glial cytokine release improves sleep & circadian rhythms in an AD mouse model, without altering amyloid levels. loom.ly/xA_XCSw #AlzheimersDisease
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Online now: Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis dlvr.it/TTvv1w
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This is the very first project I started working on during my PhD with the amazing PPSleep team, and I’m so excited to finally see it published! 🎉 🧠Replay of procedural memory is independent of the hippocampus nature.com/articles/s41593-0…
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New Online! Cellular and signalling mechanisms that regulate the blood–brain barrier dlvr.it/TTcpVq
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We will launch an Ibero-American Brain Health & Dementia Network at @FENSorg 2026 in Barcelona, with all colleagues from Latin America and Spain to strengthen collaboration in brain health and dementia research. The initiative aims to connect researchers, institutions, and existing networks around shared priorities, data integration, and cross-continental cooperation. Together with @ANavarroFPM, David Vállez García, @durananiotz, and @erzimmer, we will discuss cohort harmonization, genetics, biomarkers, neuroimaging, exposome research, data-sharing frameworks, and international funding opportunities. Looking forward to seeing many colleagues in Barcelona and shaping this next chapter together. 📍 Barcelona, Spain 📅 Monday, July 6 🕖 7:00–8:30 p.m. More information here: fens2026.abstractserver.com/…
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We now look forward to seeing many of you in person in Mexico for our first @Ibero_ICSA in-person meeting!
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How does the postnatal brain build its circadian system? ⏰🧠 A #JBR study shows that diurnal rhythms emerge across the developing mouse brain in a region- and gene-specific manner. In microglia, functional rhythms even appear before clock rhythms. journals.sagepub.com/doi/10.…..
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